Drugs / METHYLSAMIDORPHAN
METHYLSAMIDORPHAN
also known as
ALKS 37 · RDC-1036 · ALKS-37 CATION · ALKS-37 CHLORIDE · Chlorure de methylsamidorphan · Cloruro de metilsamidorfano · Methylsamidorphan cation · METHYLSAMIDORPHAN CHLORIDE · +4 more
Small molecule targets OPRM1 via inhibition
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT01418092 | Sep 2011 → Jun 2012 | opioid-induced constipation | Alkermes, Inc. | Completed | No outcome recorded |
| Phase 2 | NCT01382797 | Aug 2011 → Apr 2012 | opioid-induced constipation | Alkermes, Inc. | Completed | No outcome recorded |
| Phase 2 | NCT01100151 | Apr → Dec 2010 | opioid-induced constipation | Alkermes, Inc. | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 5
| Date | Issuer | Release |
|---|---|---|
| 2012-05-30 | Alkermes, Inc. | Results Alkermes Announces Results from Phase 2 Study of ALKS 37 for Treatment of Opioid-Induced Constipation alkermes.com ↗
Alkermes plc (NASDAQ: ALKS) today announced topline results from a phase 2b dose-ranging clinical study of ALKS 37 in the treatment of opioid-induced constipation. |
| 2011-05-09 | Alkermes, Inc. | Results Alkermes Presents Phase 2 Data of ALKS 37 in Late-Breaking Oral Session at Digestive Disease Week Meeting alkermes.com ↗
Alkermes, Inc. (NASDAQ: ALKS) today presented positive results from the phase 2 study of ALKS 37 for the treatment of opioid-induced constipation (OIC) in a late-breaking oral session at Digestive Disease Week (DDW) 2011 in Chicago. |
| 2011-02-15 | Alkermes, Inc. | Results Alkermes Announces Positive Preliminary Results from Phase 2 Study of ALKS 37 for Treatment of Opioid-Induced Bowel Dysfunction alkermes.com ↗
Data from the study showed that ALKS 37 significantly improved GI motility and increased the frequency of bowel movements in patients with OBD, while simultaneously preserving the analgesic effects of opioid treatment. |
| 2010-02-16 | Alkermes, Inc. | Results Alkermes Announces Positive Results for Phase 1 Study of New Drug Candidate for Treatment of Opioid-Induced Constipation alkermes.com ↗
Alkermes, Inc. (NASDAQ: ALKS) today announced positive topline data from a phase 1 clinical study of ALKS 37, an orally active, peripherally-restricted opioid antagonist with potential to block the effects of opioid agonists on gastrointestinal motility, commonly referred to as opioid-induced constipation (OIC). |
| 2008-11-17 | Alkermes, Inc. | Results Alkermes Presents Positive Preclinical Data on Novel, Proprietary Molecule Designed to Improve Outcomes for Patients Taking Opioid Analgesics alkermes.com ↗
Alkermes, Inc. (NASDAQ: ALKS) today announced positive preclinical results for its proprietary small molecule candidate, RDC-1036, which emerged from a library of novel opioid modulators. |
All press releases naming this drug 8 releases
Evidence & citations 17 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | METHYLSAMIDORPHAN | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | ALKS 37 | “ALK37-003: A Study of RDC-1036 (ALKS 37) in Adults With Opioid-induced Constipation (OIC)” NCT01100151 ↗ |
| Known as | ALKS-37 CATION | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | ALKS-37 CHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | Chlorure de methylsamidorphan | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | Cloruro de metilsamidorfano | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | Methylsamidorphan cation | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | METHYLSAMIDORPHAN CHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | Methylsamidorphan ion | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | RDC-1036 | “ALK37-005: A Study of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation” NCT01382797 ↗ |
| Known as | RDC-1036 CATION | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | RDC-1036-00 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Known as | RDC-1036-03 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2364619 ↗ |
| Action | Inhibit | “Mu opioid receptor antagonist” CHEMBL2364619 ↗ |
| Modality | Small molecule | — CHEMBL2364619 ↗ |
| Route | Oral | “Capsules for oral administration” NCT01100151 ↗ |
| Target | OPRM1 | “Mu opioid receptor antagonist” CHEMBL2364619 ↗ |