Drugs / DT-168
last change Sep 2026 re-read 3 minutes ago

DT-168

Developed for
Fuchs atrophia gyrata chorioideae et retinae · Fuchs' endothelial dystrophy
Investigated by
Design Therapeutics, Inc.

Trials 1

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT07024693 Jul 2025 → Sep 2026 overdue Fuchs atrophia gyrata chorioideae et retinae, Fuchs' endothelial dystrophy Design Therapeutics, Inc. Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 4

DateIssuerRelease
2025-05-07 Design Therapeutics, Inc. Results Design Therapeutics Highlights Momentum Across Lead GeneTAC® Programs and Reports First Quarter 2025 Financial Results designtx.com ↗
2025-05-01 Design Therapeutics, Inc. Results Design Therapeutics Announces Favorable Phase 1 Data for DT-168 Supporting Advancement into Phase 2 Biomarker Trial for Patients with Fuchs Endothelial Corneal Dystrophy designtx.com ↗
2024-03-19 Design Therapeutics, Inc. Regulatory Design Therapeutics Outlines Progress Across GeneTAC™ Platform and Announces Fourth Quarter and Full Year 2023 Financial Results designtx.com ↗
IND Cleared for DT-168 for Treatment of Fuchs Endothelial Corneal Dystrophy (FECD) with Phase 1 Development to Start in 2024
2023-04-24 Design Therapeutics, Inc. Results Design Therapeutics to Present Preclinical Data on its GeneTAC™ Small Molecule, DT-168, for the Treatment of Fuchs Endothelial Corneal Dystrophy at ARVO 2023 designtx.com ↗
In preclinical studies, DT-168 reduced foci in patient-derived primary corneal endothelial cells (CECs) to levels seen in cells from healthy individuals with low nanomolar IC50 values.

Evidence & citations 1 cited value

Every value below carries the sentence it was read from. 1 source stands behind the page.

FieldValueCited text
Known as DT-168 ClinicalTrials.gov intervention name — accepted as the source's own label NCT07024693 ↗