Drugs / EFLEPEDOCOKIN ALFA
EFLEPEDOCOKIN ALFA
English name Interleukin-22
also known as
F-652 · Eflepedocokina alfa · Eflepedocokine alfa · IL-22 · Il-22 dimer f-652 · Promenakin
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT02406651 | May 2016 → Apr 2019 | acute graft versus host disease | EVIVE Biotechnology | Completed | No outcome recorded |
| Phase 1/2 | NCT02655510 | Feb 2016 → Jun 2018 | alcoholic hepatitis | Mayo Clinic | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT05205668 | Apr 2022 | pneumonia | EVIVE Biotechnology | Withdrawn | No outcome recorded |
| Phase 2 | NCT04498377 | Jan → Mar 2021 | COVID-19 | EVIVE Biotechnology | Terminated | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT07060638 Comparator | Jan 2026 → Dec 2029 expected | alcoholic hepatitis | Samer Gawrieh | Recruiting | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | EFLEPEDOCOKIN ALFA | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594542 ↗ |
| Known as | Eflepedocokina alfa | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594542 ↗ |
| Known as | Eflepedocokine alfa | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594542 ↗ |
| Known as | F-652 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05205668 ↗ |
| Known as | IL-22 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07060638 ↗ |
| Known as | Il-22 dimer f-652 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594542 ↗ |
| Known as | Promenakin | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594542 ↗ |
| Modality | Protein / enzyme biologic | “a novel recombinant human interleukin-22 dimer, F-652” PMID 36399701 ↗ Mar 2023 |
| Route | Intravenous | “F-652 will be administered intravenously at a rate of 100 mL/hour for one hour once per week for four weeks.” NCT02406651 ↗ |