Drugs / AVE9633
last change Aug 2008 re-read 3 minutes ago

AVE9633

also known as HUMY9-6

targets CD33

Developed for
myeloid leukemia
Investigated by
Sanofi

Trials 1

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT00543972 Sep 2007 → Aug 2008 myeloid leukemia Sanofi Terminated No outcome recorded

News releases announcing trial results or a regulatory action · 3

DateIssuerRelease
2007-12-09 AbbVie Results ImmunoGen, Inc. Announces Encouraging Clinical Findings Reported at ASH Annual Meeting for TAP Compound AVE9633 abbvie.com ↗
AVE9633 demonstrated evidence of biological activity in multiple patients with relapsed/refractory acute myeloid leukemia (AML) and was found to be generally well tolerated.
2006-04-01 AbbVie Results ImmunoGen, Inc. Announces Eight Posters to be Presented at AACR on its TAP Technology and on Compounds in Development abbvie.com ↗
Data on the activity of the TAP compound AVE9633, now in clinical development by the sanofi-aventis Group, against human acute myeloid leukemia cells isolated from patients (abstract #5558);
2005-04-19 AbbVie Results ImmunoGen, Inc. Announces Data Reported at AACR on AVE9633 Anticancer Compound abbvie.com ↗
In vivo, AVE9633 was able to eradicate tumors consisting of human leukemia cells in xenograft models, and achieved complete responses and cures at doses that caused little or no toxicity.

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as AVE9633 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00543972 ↗
Known as HUMY9-6 ChEMBL registry synonym — accepted as the source's own label CHEMBL2109266 ↗
Route Intravenous “Intravenous Infusion” NCT00543972 ↗
Target CD33 “Myeloid cell surface antigen CD33 binding agent” CHEMBL2109266 ↗