Drugs / eftilagimod alpha
last change Feb 2026 re-read 3 minutes ago

eftilagimod alpha

Protein / enzyme biologic

Developed for
head and neck squamous cell carcinoma · breast cancer · breast carcinoma · non-small cell lung carcinoma
Investigated by
Immutep S.A.S. · Merck Sharp & Dohme LLC

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04252768 Jun 2023 → Jun 2025 breast cancer Immutep S.A.S. Withdrawn No outcome recorded
Phase 22 trials · 1 met primary
Phase 2 NCT04811027 Aug 2021 → Mar 2024 head and neck squamous cell carcinoma Immutep S.A.S. Completed No outcome recorded
Phase 2 NCT03625323 Feb 2019 → Jun 2022 head and neck squamous cell carcinoma, non-small cell lung carcinoma Immutep S.A.S. Completed Met primary
Phase 2/31 trial
Phase 2/3 NCT05747794 May 2023 → Oct 2026 expected breast carcinoma Immutep S.A.S. Active not recruiting No outcome recorded

Press releases naming this drug 37 releases

DateIssuerRelease
2023-09-20 Immutep S.A.S. Commercial Manufacturing of Eftilagimod Alpha at 2000L Scale Granted Authorization for Clinical Trial Use immutep.com ↗
2023-06-27 Immutep S.A.S. Immutep Secures Third United States Patent for Eftilagimod Alpha in Combination with a PD-1 Pathway Inhibitor immutep.com ↗
2023-05-15 Immutep S.A.S. Immutep Receives Positive Feedback from FDA on Late-Stage Clinical Development of Eftilagimod Alpha in Non-Small Cell Lung Cancer immutep.com ↗
2023-05-02 Immutep S.A.S. Immutep Announces KOL Event Focused on Eftilagimod Alpha in Non-Small Cell Lung Cancer and Head & Neck Squamous Cell Carcinoma immutep.com ↗
2023-04-30 Immutep S.A.S. Immutep Receives Approval to Initiate INSIGHT-005 Trial Evaluating Eftilagimod Alpha and Anti-PD-L1 Therapy BAVENCIO® immutep.com ↗
2023-03-13 Immutep S.A.S. Immutep Announces Initiation of Phase II/III Trial for Eftilagimod Alpha plus Paclitaxel in Metastatic Breast Cancer immutep.com ↗
2022-12-22 Immutep S.A.S. Immutep Announces Successful Meeting with the FDA on Eftilagimod Alpha plus Chemotherapy for the Treatment of Metastatic Breast Cancer immutep.com ↗
2022-12-07 Immutep S.A.S. Immutep Successfully Achieves Commercial Scale in Manufacturing of Eftilagimod Alpha immutep.com ↗
2022-11-28 Immutep S.A.S. Immutep Enters into Second Clinical Trial Collaboration Agreement with Merck KGaA, Darmstadt, Germany, and Pfizer for New Combination Study of its First-in-Class LAG-3 Candidate, Eftilagimod Alpha, and Avelumab to Treat Urothelial Cancer immutep.com ↗
2022-11-09 Immutep S.A.S. Immutep Granted New Patents in Japan and South Korea for First-in-Class LAG-3 Candidate, Eftilagimod Alpha in Chemo-Immunotherapy Combination immutep.com ↗
2022-11-09 Immutep S.A.S. Immutep Announces Compelling Clinical Results from Phase II Trial Utilizing its First-in-Class Soluble LAG-3 Protein, Eftilagimod Alpha, in 1st Line NSCLC at SITC 2022 Annual Meeting immutep.com ↗
2022-11-03 Immutep S.A.S. Immutep Announces Abstract Highlighting Eftilagimod Alpha Selected for SITC 2022 Annual Meeting Press Conference immutep.com ↗

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as eftilagimod alpha ClinicalTrials.gov intervention name — accepted as the source's own label NCT05747794 ↗
3

NCT03625323 ↗

NCT04811027 ↗

NCT04252768 ↗

Action Activate “APC activator, MHC II agonist, LAG-3 fusion protein” NCT03625323 ↗
Modality Protein / enzyme biologic “Eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein” PMID 39403626 ↗ Aug 2024
Route Subcutaneous “patients received efti (30 mg subcutaneously every 2 weeks for eight 3-week cycles and then every 3 weeks for up to 54 weeks)” PMID 39403626 ↗ Aug 2024