Drugs / KW-2450
last change Dec 2012 re-read 9 days ago

KW-2450

Small molecule targets IGF1R, INSR via inhibition

Developed for
breast cancer · cancer
Investigated by
Kyowa Hakko Kirin Pharma, Inc. · Kyowa Kirin, Inc.

Trials 2

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT01199367 Dec 2010 → Dec 2012 breast cancer Kyowa Kirin, Inc. Terminated No outcome recorded
Phase 1 NCT00921336 Jun 2009 → Aug 2010 cancer Kyowa Kirin, Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as KW-2450 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01199367 ↗
1

NCT00921336 ↗

Action Inhibit “Insulin-like growth factor I receptor inhibitor” CHEMBL5315324 ↗
1

“Insulin receptor inhibitor” CHEMBL5315324 ↗

Modality Small molecule — CHEMBL5315324 ↗
Route Oral “Subjects at each dose level will receive KW-2450 orally, once daily for 28 days followed by a 1-week observation period.” NCT00921336 ↗
Target IGF1R “Insulin-like growth factor I receptor inhibitor” CHEMBL5315324 ↗
Target INSR “Insulin receptor inhibitor” CHEMBL5315324 ↗