Drugs / Pentamidine

Trials 25 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03730363 Dec 2018 → May 2019 classic Hodgkin lymphoma Reinhold Munker Completed No outcome recorded
Phase 1 NCT02210182 Aug 2014 → Dec 2015 hepatocellular carcinoma Oncozyme Pharma Inc. Completed No outcome recorded
Phase 1 NCT00001027 ? → Sep 1996 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT00810953 Jan 2009 → Jun 2010 malignant pancreatic neoplasm Oncozyme Pharma Inc. Completed No outcome recorded
Phase 1/2 NCT00809796 Mar 2008 → May 2011 colorectal cancer Oncozyme Pharma Inc. Completed No outcome recorded
Phase 24 trials
Phase 2 NCT06550609 Feb 2025 → Nov 2027 expected mucocutaneous leishmaniasis Fundacion Nacional de Dermatologia Recruiting No outcome recorded
Phase 2 NCT03445897 Jan 2016 → Jan 2018 cutaneous leishmaniasis Jonathan Berman Completed No outcome recorded
Phase 2 NCT02919605 Jan 2014 → Jan 2016 cutaneous leishmaniasis Fundação de Medicina Tropical Dr. Heitor Vieira Dourado Completed No outcome recorded
Phase 2 NCT00729807 Jul 2008 → Aug 2012 cutaneous melanoma University of Maryland, Baltimore Terminated No outcome recorded
Phase 36 trials
Phase 3 NCT01360762 Nov 2011 → Nov 2015 HIV infectious disease, visceral leishmaniasis Institute of Tropical Medicine, Belgium Completed No outcome recorded
Phase 3 NCT00000727 ? → Aug 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000730 ? → Mar 1989 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 3 NCT00000715 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001028 ? → Jun 1994 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001013 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 41 trial
Phase 4 NCT07357103 Mar 2026 → Mar 2029 expected pneumocystosis McGill University Health Centre/Research Institute of the McGill University Health Centre Not yet recruiting No outcome recorded
Phase not applicable9 trials
NCT00002056 HIV infectious disease, pneumocystosis LyphoMed Completed No outcome recorded
NCT00002292 HIV infectious disease, pneumocystosis LyphoMed Completed No outcome recorded
NCT00000707 ? → Jun 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
NCT00002291 HIV infectious disease, pneumocystosis Fisons Completed No outcome recorded
NCT00000722 ? → Jun 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
NCT00001003 ? → Jan 1992 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
NCT00002054 HIV infectious disease, pneumocystosis Fisons Completed No outcome recorded
NCT00002030 HIV infectious disease, pneumocystosis Fisons Completed No outcome recorded
NCT00002055 HIV infectious disease, pneumocystosis Fisons Completed No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT00078559 Background Nov 2003 → Feb 2010 kidney disorder University of Wisconsin, Madison Completed No outcome recorded
Phase 23 trials
Phase 2 NCT00803933 Comparator Feb 2003 → Feb 2004 human African trypanosomiasis Immtech Pharmaceuticals, Inc Completed No outcome recorded
Phase 2 NCT00014911 Background Apr 2001 → Jun 2005 type 1 diabetes mellitus National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT00002524 Background Jun 1993 → Oct 2005 lymphoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03096457 Comparator Apr 2017 → Mar 2018 cutaneous leishmaniasis Fundacion Nacional de Dermatologia Completed No outcome recorded
Phase 41 trial
Phase 4 NCT00636935 Background Feb 2008 → Aug 2013 pneumocystosis George Washington University Withdrawn No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 32 sources stand behind the page.

FieldValueCited text
Known as Pentamidine “antibiotics (Bactrim, Pentamidine, Atovaquone, Primaquine/Clindamycin, or Trimethoprim/Dapsone)” NCT00636935
30

pentamidine inhaled 300 mg / d” NCT06550609

NCT00002054

NCT00001013

NCT00001003

NCT00014911

NCT00002030

NCT03445897

NCT00002292

NCT00000722

NCT00002291

NCT00002056

NCT00078559

NCT00002055

NCT00002524

NCT00000727

NCT00000730

NCT00810953

NCT02919605

NCT02210182

NCT00729807

NCT00000715

NCT07357103

NCT00803933

NCT01360762

NCT00000707

NCT00001027

NCT00809796

NCT03096457

NCT03730363

NCT00001028

Known as Lomidine “Pentamidine was initially used as metanolsulfonate or mesylate (Lomidine) at a dose of 4 mg/kg/daily, containing 2.3mg of base.” PMID 30379814 Oct 2018
Known as Pentamidine isethionate Pentamidine isethionate 300 mg for one vial for intramuscular or intravenous route(1 mg of pentamidine isethionate is equivalent to 0.57 mg of pentamidine base)” NCT01360762
2

Pentamidine isethionate (Aventis) for injection (200 mg/vial), 4 mg/kg QD IM” NCT00803933

“Drug: Pentamidine IsethionateNCT03096457

Route Inhaled “The aerosol therapy is given by a respiratory therapist 5 times a week” NCT00000707