Drugs / 5-fluouracil
last change Sep 2025 re-read 2 minutes ago

5-fluouracil

also known as 5-fluouracil (5-FU) · 5-FU
Developed for
cancer · malignant pancreatic neoplasm · metastatic neoplasm · pancreatic ductal adenocarcinoma
Investigated by
Servier · Shanghai Henlius Biotech · University of Cologne

Trials 2 · a red edge is where a trial was stopped

20192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT03577704 Aug 2018 → Sep 2022 cancer Shanghai Henlius Biotech Completed No outcome recorded
Phase 21 trial
Phase 2 NCT04617457 Oct 2021 → Dec 2024 malignant pancreatic neoplasm, metastatic neoplasm University of Cologne Unknown No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT04469556 Comparator Oct 2020 → Mar 2025 pancreatic ductal adenocarcinoma University Health Network, Toronto Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03344068 Background Jan 2018 → Dec 2020 nasopharyngeal carcinoma Sun Yat-sen University Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT01588990 Background Jun 2012 → Sep 2016 colorectal cancer Hoffmann-La Roche Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as 5-Fluouracil “mFOLFOX6 protocol: oxaliplatin (85 mg/m2), leucovorin (400 mg/m2), and 5-fluouracil (5-FU) (400 mg/m2, followed by 2400 mg/m2), every 2 weeks.” NCT03577704
4

“Modified FOLFIRINOX (Folinic acid/Leucovorin, 5-Fluouracil, Irinotecan, Oxaliplatin) administered intravenously.” NCT04469556

“Nedaplatin 80mg/m2 d1+5-fluouracil 500mg/m2 d2-5, every 3 weeks; a total of 2-3 cycles.” NCT03344068

NCT04617457

NCT01588990

Known as 5-fluouracil (5-FU) 5-fluouracil (5-FU)NCT04617457
Known as 5-FU “mFOLFOX6 protocol: oxaliplatin (85 mg/m2), leucovorin (400 mg/m2), and 5-fluouracil (5-FU) (400 mg/m2, followed by 2400 mg/m2), every 2 weeks.” NCT03577704
Route Intravenous “400 mg/m\^2 IV” NCT01588990