Drugs / BAY1093884
last change Jul 2020 re-read 3 minutes ago

BAY1093884

also known as Befovacimab

Monoclonal antibody targets TFPI via inhibition

Developed for
hemophilia · hemophilia A · hemophilia B
Investigated by
Bayer

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03996486 Oct 2019 → May 2020 hemophilia Bayer Withdrawn No outcome recorded
Phase 1 NCT03481946 May → Oct 2018 hemophilia A, hemophilia B Bayer Completed No outcome recorded
Phase 1 NCT02571569 Oct 2015 → Jul 2018 hemophilia A, hemophilia B Bayer Completed No outcome recorded
Phase 21 trial
Phase 2 NCT03597022 Jul 2018 → Oct 2019 hemophilia Bayer Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as BAY1093884 “Befovacimab (BAY1093884)” NCT03597022 ↗
3

NCT02571569 ↗

NCT03481946 ↗

NCT03996486 ↗

Known as Befovacimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT03597022 ↗
Action Inhibit “antibody blocking the endogenous tissue factor pathway inhibitor (TFPI)” NCT03996486 ↗
Modality Monoclonal antibody “Human monoclonal immunoglobulin G2 antibody” NCT03996486 ↗
Route Intravenous “Drug will be administered via IV infusion over 1 hour and SC injection.” NCT02571569 ↗
Route Subcutaneous “Drug will be administered via IV infusion over 1 hour and SC injection.” NCT02571569 ↗
Target TFPI “blocking the endogenous tissue factor pathway inhibitor (TFPI)” NCT03996486 ↗