Novobiocin

also known as Albamycin · Albamycin t · Calcium novobiocin · Cathomycin · NOVOBIOCIN CALCIUM · Novobiocin monosodium salt · novobiocin sodium · Novobiocin, calcium salt · +6 more

Small molecule

Developed for: metastatic malignant neoplasm
Investigated by: National Cancer Institute (NCI)

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	ALBAMYCIN	—	1964-09-04	fda.gov ↗

Trials 1 · a red edge is where a trial was stopped

today

US approved 1964

NCT05687110 · Ph 1

196319641965196619671968196919701971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1	NCT05687110	Jul 2023 → Aug 2026 overdue	metastatic malignant neoplasm	National Cancer Institute (NCI)	Recruiting	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 0	NCT02099240 Comparator	Mar 2014 → Nov 2018	osteomyelitis	University of Louisville	Terminated	No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

Field	Value	Cited text
Known as	Novobiocin	“Novobiocin” NCT02099240 ↗ 1 NCT05687110 ↗
Known as	Albamycin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Albamycin t	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Calcium novobiocin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Cathomycin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	NOVOBIOCIN CALCIUM	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Novobiocin monosodium salt	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	novobiocin sodium	“To determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of novobiocin sodium (novobiocin) administered on a 5-days on/2-days off schedule” NCT05687110 ↗
Known as	Novobiocin, calcium salt	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Novobiocina	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Novobiocine	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	NSC-2382	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Sodium novobiocin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Spheromycin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Known as	Vulcamycin	ChEMBL registry synonym — accepted as the source's own label CHEMBL36506 ↗
Action	Inhibit	“Novobiocin is an antibiotic that blocks the activity of a protein called DNA polymerase theta” NCT05687110 ↗
Modality	Small molecule	— CHEMBL36506 ↗
Route	Oral	“Patients receive novobiocin sodium orally (PO) once daily (QD)” NCT05687110 ↗