Drugs / BNC210
last change Sep 2025 re-read 3 minutes ago

BNC210

also known as Iw-2143

targets CHRNA7 via inhibition

Developed for
post-traumatic stress disorder · social phobia
Investigated by
Bionomics Limited

Trials 5

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 24 trials · 1 missed
Phase 2 NCT05193409 Feb → Oct 2022 social phobia Bionomics Limited Completed Missed primary
Phase 2 NCT04951076 Jul 2021 → Jul 2023 post-traumatic stress disorder Bionomics Limited Completed No outcome recorded
Phase 2 NCT03548194 May 2018 → Apr 2019 — Bionomics Limited Completed No outcome recorded
Phase 2 NCT02933606 Jun 2016 → Jul 2018 post-traumatic stress disorder Bionomics Limited Completed No outcome recorded
Phase 31 trial · 1 missed
Phase 3 NCT06510504 Aug 2024 → Sep 2025 social phobia Bionomics Limited Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as BNC210 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05193409 ↗
4

NCT03548194 ↗

NCT06510504 ↗

NCT02933606 ↗

NCT04951076 ↗

Known as Iw-2143 ChEMBL registry synonym — accepted as the source's own label CHEMBL4650452 ↗
Action Inhibit “BNC210 is a novel α7 nicotinic acetylcholine receptor-negative allosteric modulator developed to treat PTSD.” PMID 39647171 ↗ Dec 2024
1

“Neuronal acetylcholine receptor protein alpha-7 subunit negative allosteric modulator” CHEMBL4650452 ↗

Route Oral “Suspension administered orally for 12 weeks.” NCT02933606 ↗
Target CHRNA7 “Neuronal acetylcholine receptor protein alpha-7 subunit negative allosteric modulator” CHEMBL4650452 ↗