Drugs / DYP688
last change Jul 2026 re-read 3 minutes ago

DYP688

targets PMEL

Developed for
uveal melanoma
Investigated by
Novartis Pharmaceuticals

Trials 1

20232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT05415072 Jul 2022 → Oct 2027 expected uveal melanoma Novartis Pharmaceuticals Active not recruiting No outcome recorded

Evidence & citations 2 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as DYP688 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05415072 ↗
Target PMEL “binds surface PMEL and delivers the potent Gαq/Gα11 (Gq/11) inhibitor SDZ475 as payload by internalization.” PMID 42443515 ↗ Jul 2026