Drugs / Quadrivalent HPV vaccine

Trials 5

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 23 trials
Phase 2 NCT04096911 Jul 2019 → Mar 2021 cervical cancer Buhai Wang Unknown No outcome recorded
Phase 2 NCT01492582 Jul 2012 → Feb 2019 — University of Alabama at Birmingham Completed Mixed
Phase 2 NCT00604175 Feb 2008 → Jan 2012 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 32 trials · 1 missed
Phase 3 NCT02009800 Nov 2013 → Dec 2021 human papilloma virus infection CHU de Quebec-Universite Laval Completed No outcome recorded
Phase 3 NCT01461096 Mar 2012 → Dec 2015 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed Missed primary
Comparator or background therapy1 trial
Phase 3 NCT02750202 Comparator Jul 2018 → Jul 2025 anogenital human papillomavirus infection University of Pretoria Completed No outcome recorded

Press releases naming this drug 22 releases

DateIssuerRelease
2026-03-17 Merck Sharp & Dohme LLC Merck to Present New Data Reinforcing Long-Term Efficacy of GARDASIL®9 and GARDASIL® at the EUROGIN International Multidisciplinary HPV Congress 2026 merck.com ↗
2025-05-23 Merck Sharp & Dohme LLC Merck Statement on a Potential Reduced Dosing Recommendation for GARDASIL®9 merck.com ↗
2025-01-08 Merck Sharp & Dohme LLC Merck’s GARDASIL® Receives Expanded Approval for Males in China merck.com ↗
2024-11-12 Merck Sharp & Dohme LLC Merck to Present New Data From GARDASIL®9 Studies Reinforcing the Importance of Gender-Neutral HPV Vaccination in Adults Up to Age 45 at the International Papillomavirus Conference (IPVC) 2024 merck.com ↗
2024-09-11 Merck Sharp & Dohme LLC Merck Announces Positive Top-line Results from Phase 3 Trial Evaluating Efficacy and Safety of GARDASIL®9 in Japanese Males merck.com ↗
2024-03-13 Merck Sharp & Dohme LLC Merck Announces Plans to Conduct Clinical Trials of a Novel Investigational Multi-Valent Human Papillomavirus (HPV) Vaccine and Single-Dose Regimen for GARDASIL®9 merck.com ↗
2023-09-05 Merck Sharp & Dohme LLC Long-Term Follow-up Data on Sustained Immunogenicity and Safety for GARDASIL®9 Published in Pediatrics merck.com ↗
2022-11-07 Merck Sharp & Dohme LLC Reductions in Certain Types of HPV-Related Cervical and Non-Cervical Diseases in Women and Men Observed with Real-World Use of Merck’s GARDASIL® in Systematic Literature Review of 138 Studies merck.com ↗
2020-06-12 Merck Sharp & Dohme LLC FDA Approves Merck’s GARDASIL 9 for the Prevention of Certain HPV-Related Head and Neck Cancers merck.com ↗
2019-06-26 Merck Sharp & Dohme LLC CDC Advisory Committee on Immunization Practices (ACIP) Votes to Provisionally Recommend Shared Clinical Decision-Making for Vaccination of Adults Ages 27-45 with GARDASIL®9 & Harmonization of Catch-up Vaccination for Males and Females Through Age 26 merck.com ↗
2018-06-13 Merck Sharp & Dohme LLC FDA Grants Priority Review to Merck’s Supplemental Biologics License Application (sBLA) for GARDASIL®9 in Women and Men Ages 27 to 45 for the Prevention of Certain HPV-Related Cancers and Diseases merck.com ↗
2017-10-10 Merck Sharp & Dohme LLC Six-year Efficacy Data for GARDASIL® 9 Presented at EUROGIN 2017 Congress merck.com ↗

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Quadrivalent HPV vaccine “Participants received three intramuscular doses of either quadrivalent HPV vaccine (HPV4; enrolments on or before March 1, 2016) or nonavalent HPV vaccine (HPV9; enrolments...” PMID 34767765 ↗ Nov 2021
5

NCT00604175 ↗

NCT02750202 ↗

NCT04096911 ↗

NCT01461096 ↗

NCT02009800 ↗

Known as 4vHPV “There are no randomized studies comparing the long-term effectiveness of a 2-dose schedule (administered at 0 and 6 months) of quadrivalent human papillomavirus vaccine (4vHPV)...” PMID 40627355 ↗ Jul 2025
Known as Gardasil “Food and Drug Administration (FDA)-approved quadrivalent HPV vaccine, Gardasil, at preventing anal HPV infection” NCT01461096 ↗
Known as HPV4 “Participants received three intramuscular doses of either quadrivalent HPV vaccine (HPV4; enrolments on or before March 1, 2016) or nonavalent HPV vaccine (HPV9; enrolments...” PMID 34767765 ↗ Nov 2021
Modality Vaccine “Quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine.” NCT00604175 ↗
Route Intramuscular “via intramuscular injection” NCT00604175 ↗