Drugs / Pralidoxime
Pralidoxime
also known as
2-PAM · 2-PAM CHLORIDE · Atnaa · Contrathion · Iodure de pralidoxime · Ioduro de pralidoxima · NSC-164614 · NSC-40164 · +14 more
Small molecule targets ACHE via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | PROTOPAM CHLORIDE | — | 1964-03-11 | fda.gov ↗ |
Trials 2 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT06111352 | Jun 2022 → Sep 2023 | organophosphate poisoning | Sir Salimullah Medical College Mitford Hospital | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT00333944 | May 2000 → Jun 2003 | organophosphate poisoning | Giriraj Hospital | Completed | No outcome recorded |
Also used as a comparator or background therapy in 2 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02040350 Comparator | Apr 2012 → Aug 2013 | — | Sheri Kashmir Institute of Medical Sciences | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02160548 Comparator | Apr → Dec 2015 | organophosphate poisoning | Sylhet M.A.G.Osmani Medical College | Completed | No outcome recorded |
Evidence & citations 27 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Pralidoxime | “Pralidoxime (acetylcholinesterase reactivating oxime drug; PAM-A) by intravenous route” NCT02160548 ↗ |
| Known as | 2-PAM | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | 2-PAM CHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Atnaa | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Contrathion | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Iodure de pralidoxime | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Ioduro de pralidoxima | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | NSC-164614 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | NSC-40164 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | NSC-7760 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime cation | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | PRALIDOXIME CHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime chloride (autoinjector) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime chloride component of atnaa | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime chloride component of duodote | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | PRALIDOXIME IODIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime ion | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime mesilate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | PRALIDOXIME MESYLATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime methane sulphonate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Pralidoxime methanesulfonate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Protopam | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Known as | Protopam chloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1420 ↗ |
| Action | Activate | “Acetylcholinesterase activator” CHEMBL1420 ↗ |
| Modality | Small molecule | — CHEMBL1420 ↗ |
| Route | Intravenous | “30mg/kg bolus I.V over 20 min followed by 8mg/kg/hr continuous infusion” NCT02040350 ↗ |
| Target | ACHE | “Acetylcholinesterase activator” CHEMBL1420 ↗ |