Drugs / D-Penicillamine
last change Sep 2026 re-read 9 days ago

D-Penicillamine

also known as DPA
Developed for
lead poisoning · vascular occlusion disorder · Wilson disease
Investigated by
Bezoloven, Inc. · FDA Office of Orphan Products Development

Trials 1

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2/31 trial
Phase 2/3 NCT00552630 Sep 2007 → ? lead poisoning, vitamin D deficiency FDA Office of Orphan Products Development Withdrawn No outcome recorded
Comparator or background therapy3 trials
Phase 2 NCT03106948 Comparator Feb 2017 → Jan 2018 vascular occlusion disorder Southeast Renal Research Institute Unknown No outcome recorded
Phase 3 NCT07465718 Comparator Sep 2026 → Feb 2028 expected Wilson disease Orphalan Recruiting No outcome recorded
Phase 3 NCT03660059 Background Sep 2018 → Apr 2021 rheumatoid arthritis Astellas Pharma Inc Completed Met primary

Evidence & citations 2 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as D-Penicillamine “hydroxychloroquine, salazosulfapyridine, gold (injection or oral), D-penicillamine, lobenzarit, actarit, bucillamine and iguratimod.” NCT03660059 ↗
3

“d-penicillamine twice daily, 15 mg/kg/day, for 6 weeks” NCT00552630 ↗

“D-Penicillamine” NCT03106948 ↗

NCT07465718 ↗

Known as DPA “d-Penicillamine (DPA) is currently the only approved first line chelator for the treatment of WD” NCT07465718 ↗