Drugs / D-Penicillamine
last change Jul 2026 re-read 2 minutes ago

D-Penicillamine

also known as DPA
Developed for
lead poisoning · vascular occlusion disorder · Wilson disease
Investigated by
Bezoloven, Inc. · FDA Office of Orphan Products Development

Trials 1 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2/3 NCT00552630 Sep 2007 → ? lead poisoning, vitamin D deficiency FDA Office of Orphan Products Development Withdrawn No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT03106948 Comparator Feb 2017 → Jan 2018 vascular occlusion disorder Southeast Renal Research Institute Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT07465718 Comparator Jul 2026 → Feb 2028 expected Wilson disease Orphalan Not yet recruiting No outcome recorded
Phase 3 NCT03660059 Background Sep 2018 → Apr 2021 rheumatoid arthritis Astellas Pharma Inc Completed No outcome recorded

Evidence & citations 2 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as D-penicillamine “hydroxychloroquine, salazosulfapyridine, gold (injection or oral), D-penicillamine, lobenzarit, actarit, bucillamine and iguratimod.” NCT03660059
3

d-penicillamine twice daily, 15 mg/kg/day, for 6 weeks” NCT00552630

D-PenicillamineNCT03106948

NCT07465718

Known as DPA “d-Penicillamine (DPA) is currently the only approved first line chelator for the treatment of WD” NCT07465718