Drugs / Doxycycline hyclate
Doxycycline hyclate
also known as
Acticlate · Acticlate cap · Atridox · Azudoxat · Clinofug · Cyclodox · Demix 100 · Demix 50 · +40 more
Small molecule targets MMP1, MMP13, MMP7, MMP8 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 11 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (4) | US (FDA) | DORYX MPC | — | 2006-12-19 – 2017-05-31 | fda.gov ↗ |
| Label expansions (3) | US (FDA) | VIBRA-TABS | — | 1984-01-17 – 1992-12-15 | fda.gov ↗ |
| Label expansions (3) | US (FDA) | VIBRAMYCIN | — | 1972-12-11 – 1977-09-21 | fda.gov ↗ |
| Approved | US (FDA) | VIBRAMYCIN | — | 1967-12-05 | fda.gov ↗ |
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials | ||||||
| Phase 2 | NCT04723069 | Sep 2021 → Mar 2022 | pelvic inflammatory disease | University of Karachi | Completed | No outcome recorded |
| Phase 2 | NCT03637400 | Nov 2018 → Feb 2024 | methicillin-resistant staphylococcus aureus infectious disease, skin infection | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Completed | No outcome recorded |
| Phase 2 | NCT01087476 | May 2010 → Jun 2011 | chemotherapy-induced oral mucositis | Metropolitan Autonomous University | Unknown | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT04451330 | Jul 2020 → Apr 2021 | acne | Galderma R&D | Completed | No outcome recorded |
Also used as a comparator or background therapy in 2 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT01499225 Comparator | Dec 2011 → Jul 2013 | chronic periodontitis | Yuhan Corporation | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT04582383 Comparator | Mar 2022 → Feb 2026 overdue | acne | University of Pennsylvania | Active not recruiting | No outcome recorded |
Evidence & citations 56 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Doxycycline hyclate | “Doxycycline hyclate tablets are consecutively taken for 14 days” NCT04723069 ↗ |
| Known as | Acticlate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Acticlate cap | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Atridox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Azudoxat | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Clinofug | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Cyclodox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Demix 100 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Demix 50 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | DENTISTA | “DENTISTA[Doxycycline hyclate] 20mg Cap” NCT01499225 ↗ |
| Known as | Diocimex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doryx | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doryx mpc | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxatet | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxiciclina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxicrisol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | DOXY | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03637400 ↗ |
| Known as | Doxy 100 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxy 200 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxy-lemmon | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxychel hyclate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxycycline hydrochloride hemiethanolate hemihydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxycycline hydrochloride hydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxycyclini hyclas | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxylar | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Doxyprex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Duradoxal | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Granudoxy | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Lymepak | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Mespafin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Monodoks | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | NSC-741421 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Periostat | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Ramysis | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Retens | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Ronaxan | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Spanor | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Tetraclean | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Tetradox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Unacil | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibra-tabs | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibramycin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibramycin 50 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibramycin acne pack | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibramycin-d | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibraveineuse | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibravenos | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Vibrox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Known as | Zadorin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1433 ↗ |
| Action | Inhibit | “Matrix metalloproteinase 13 inhibitor” CHEMBL1433 ↗3“Matrix metalloproteinase 7 inhibitor” CHEMBL1433 ↗ “Matrix metalloproteinase-1 inhibitor” CHEMBL1433 ↗ “Matrix metalloproteinase 8 inhibitor” CHEMBL1433 ↗ |
| Modality | Small molecule | — CHEMBL1433 ↗ |
| Route | Oral | “Doxycycline hyclate delayed release 120 mg tablets was administered orally for 12 weeks.” NCT04451330 ↗ |
| Target | MMP1 | “Matrix metalloproteinase-1 inhibitor” CHEMBL1433 ↗ |
| Target | MMP13 | “Matrix metalloproteinase 13 inhibitor” CHEMBL1433 ↗ |
| Target | MMP7 | “Matrix metalloproteinase 7 inhibitor” CHEMBL1433 ↗ |
| Target | MMP8 | “Matrix metalloproteinase 8 inhibitor” CHEMBL1433 ↗ |