Drugs / Albinterferon Alfa-2b
last change Jan 2015 re-read 2 minutes ago

Albinterferon Alfa-2b

also known as albIFN · Albinterferon

Protein / enzyme biologic

Developed for
chronic hepatitis C virus infection · chronic hepatitis B virus infection
Investigated by
Human Genome Sciences Inc. · Novartis · Novartis Pharmaceuticals

Trials 4 · a red edge is where a trial was stopped

200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00724776 Jul 2008 → Jul 2009 chronic hepatitis C virus infection Novartis Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00964665 Jul 2009 → Nov 2010 chronic hepatitis B virus infection Novartis Pharmaceuticals Terminated No outcome recorded
Phase 21 trial
Phase 2 NCT00759200 Oct 2008 → Dec 2010 chronic hepatitis C virus infection Novartis Completed No outcome recorded
Phase 31 trial
Phase 3 NCT00411385 Feb 2007 → Oct 2008 chronic hepatitis C virus infection Human Genome Sciences Inc. Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Albinterferon alfa-2b Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 2 or 3.” PMID 20600017 Jul 2010
4

Albinterferon alfa-2b (albIFN) is a fusion protein of recombinant human albumin/recombinant interferon (IFN)-α-2b” PMID 22863266 Mar 2012

NCT00759200

NCT00964665

NCT00724776

Known as albIFN “a phase 3 active-controlled study was conducted to assess the efficacy/safety of albinterferon alfa-2b (albIFN), a novel, long-acting, genetic fusion polypeptide of recombinant...” PMID 20600017 Jul 2010
2

“This study will evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of albinterferon alfa 2b (alb-IFN) single dose in Japanese chronic hepatitis C patients” NCT00724776

“Albinterferon alfa-2b (albIFN) is a fusion protein of recombinant human albumin/recombinant interferon (IFN)-α-2b” PMID 22863266 Mar 2012

Known as Albinterferon Albinterferon is a fusion of albumin and interferon-α2b developed to improve the pharmacokinetics, convenience, and potential efficacy of interferon-α for the treatment of...” PMID 24995515 Jan 2015
Modality Protein / enzyme biologic “a novel, long-acting, genetic fusion polypeptide of recombinant human albumin and interferon alfa-2b” PMID 20600017 Jul 2010
Route Subcutaneous “open-label subcutaneous treatment with pegylated interferon-alfa-2a (Peg-IFNalfa-2a) 180 μg/wk, or albIFN 900 or 1200 μg every 2 weeks for 24 weeks” PMID 20600017 Jul 2010