Drugs / ERFONRILIMAB

Trials 28 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04040699 Sep 2019 → Sep 2022 HER2 positive breast carcinoma Peking University Completed No outcome recorded
Phase 1 NCT03733951 Dec 2018 → Jan 2023 cancer, lymphoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Completed No outcome recorded
Phase 1 NCT03529526 May 2018 → Oct 2019 cancer Alphamab (Australia) Co Pty Ltd. Unknown No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT05832892 Nov 2023 → Nov 2024 neoplastic disease or syndrome Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 1/2 NCT05827796 Dec 2022 → Dec 2025 overdue malignant pancreatic neoplasm InxMed (Shanghai) Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT04984668 Nov 2021 → Apr 2025 cancer Suzhou Kintor Pharmaceutical Inc Unknown No outcome recorded
Phase 1/2 NCT04601610 Jun 2021 → May 2022 hepatocellular carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Terminated No outcome recorded
Phase 1/2 NCT04612712 Jan 2021 → Jun 2022 Suzhou Zelgen Biopharmaceuticals Co.,Ltd Terminated No outcome recorded
Phase 1/2 NCT03872791 May 2019 → Aug 2022 triple-negative breast carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Completed No outcome recorded
Phase 215 trials
Phase 2 NCT05985109 Oct 2023 → Dec 2026 expected colorectal cancer Peking University Cancer Hospital & Institute Recruiting No outcome recorded
Phase 2 NCT06099821 Oct 2023 → Dec 2026 expected digestive system cancer Peking University Cancer Hospital & Institute Recruiting No outcome recorded
Phase 2 NCT06023758 Sep 2023 → Sep 2025 overdue carcinoma Peking University Recruiting No outcome recorded
Phase 2 NCT05985707 Aug 2023 → Dec 2026 expected carcinoma Peking University Cancer Hospital & Institute Not yet recruiting No outcome recorded
Phase 2 NCT06834399 Apr 2023 → Dec 2024 colorectal cancer Zhejiang Raygene Pharmaceuticals Co., Ltd Terminated No outcome recorded
Phase 2 NCT05420220 Jul 2022 → Dec 2024 non-small cell lung carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Completed No outcome recorded
Phase 2 NCT04925947 Dec 2021 → May 2023 thymic carcinoma Weill Medical College of Cornell University Terminated No outcome recorded
Phase 2 NCT04521179 Dec 2020 → Jan 2022 Jiangsu Alphamab Biopharmaceuticals Co., Ltd Completed No outcome recorded
Phase 2 NCT04469725 Dec 2020 → Jul 2023 thymic carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Terminated No outcome recorded
Phase 2 NCT04542837 Sep 2020 → Feb 2022 hepatocellular carcinoma Peking University Cancer Hospital & Institute Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT06020352 Aug 2023 → Jul 2025 non-small cell lung carcinoma Shanghai Pulmonary Hospital, Shanghai, China Unknown No outcome recorded
Phase 2/3 NCT05001724 Oct 2021 → Feb 2023 non-small cell lung carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Terminated No outcome recorded
Phase 32 trials
Phase 3 NCT05149326 Jan 2022 → Apr 2024 pancreatic ductal adenocarcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Unknown No outcome recorded
Phase 3 NCT04474119 Sep 2020 → Aug 2022 non-small cell squamous lung carcinoma Jiangsu Alphamab Biopharmaceuticals Co., Ltd Unknown No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT05425602 Background Jul 2022 → Dec 2023 Maxinovel Pty., Ltd. Unknown No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 30 sources stand behind the page.

FieldValueCited text
Known as ERFONRILIMAB ChEMBL registry synonym — accepted as the source's own label CHEMBL4650483
Known as KN046 “This study aimed to evaluate the efficacy and safety of KN046, a novel recombinant humanised antibody targeting PD-L1 and CTLA-4 in advanced non-small cell lung cancer (NSCLC)...” PMID 37393762 Jun 2023
28

“and the dose of KN046 was 5 mg/kg as a fixed dose administered every 3 weeks.” NCT05425602

KN046 is a PD-L1 - CTLA-4 bispecific antibody.” NCT04521179

“30 mg/kg Q3W KN026 5 mg/kg Q3W KN046NCT04165993

NCT04469725

NCT05420220

NCT03927495

NCT05827796

NCT04925947

NCT04612712

NCT06099821

NCT05149326

NCT04054531

NCT06023758

NCT05832892

NCT03529526

NCT03872791

NCT04474119

NCT05985109

NCT03925870

NCT06020352

NCT04984668

NCT06834399

NCT03733951

NCT04040699

NCT04542837

NCT05985707

NCT05001724

NCT04601610

Action Inhibit “Programmed cell death 1 ligand 1 inhibitor” CHEMBL4650483
2

“Cytotoxic T-lymphocyte protein 4 inhibitor” CHEMBL4650483

“Anti-PD-L1 / CTLA-4 Bispecific Antibody” NCT05425602

Modality Monoclonal antibody “KN046 is a PD-L1 - CTLA-4 bispecific antibody.” NCT04521179
Route Intravenous Intravenous (IV) infusions” NCT03733951
Target CD274 “Programmed cell death 1 ligand 1 inhibitor” CHEMBL4650483
Target CTLA4 “Cytotoxic T-lymphocyte protein 4 inhibitor” CHEMBL4650483