Drugs / Modified Process Hepatitis B Vaccine
last change Sep 2014 re-read 2 minutes ago

Modified Process Hepatitis B Vaccine

also known as mpHBV

Vaccine

Developed for
hepatitis B virus infection · hepatocellular carcinoma
Investigated by
Merck Sharp & Dohme LLC

Trials 5 · a red edge is where a trial was stopped

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT00322361 May 2006 → Jul 2007 hepatitis B virus infection, hepatocellular carcinoma Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 34 trials
Phase 3 NCT00440297 Dec 2006 → May 2008 hepatitis B virus infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00440531 Nov 2006 → Nov 2007 hepatitis B virus infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00414050 Oct 2006 → Oct 2007 hepatitis B virus infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00393523 Sep 2006 → Jun 2008 hepatitis B virus infection Merck Sharp & Dohme LLC Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as Modified Process Hepatitis B Vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT00393523
4

NCT00440297

NCT00414050

NCT00322361

NCT00440531

Known as mpHBV “This study examined the immune response engendered in older adults by RECOMBIVAX HB™ manufactured using a modified adjuvant (modified-process hepatitis B vaccine; mpHBV),...” PMID 22185811 Dec 2011
3

“This modified process hepatitis B vaccine (mpHBV), which was previously shown to have an acceptable safety and immunogenicity profile in young adults, has now been studied in...” PMID 22227229 Jan 2012

“A modified process hepatitis B vaccine (mpHBV) uses higher phosphate content in the manufacturing process relative to the current product, Recombivax-HB.” PMID 21552183 Jul 2011

“A manufacturing process modification for a hepatitis B vaccine (mpHBV) was studied in renal pre-dialysis and dialysis patients.” PMID 25252192 Sep 2014

Modality Vaccine “modified process hepatitis B vaccineNCT00322361
Route Intramuscular “administered via intramuscular injection” NCT00322361