Drugs / Ulviprubart
last change Mar 2026 re-read 3 minutes ago

Ulviprubart

also known as ABC008

Monoclonal antibody

Developed for
inclusion body myositis · T-cell large granular lymphocyte leukemia
Investigated by
Abcuro, Inc.

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04659031 May 2021 → Jan 2025 inclusion body myositis Abcuro, Inc. Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT05532722 Sep 2022 → Aug 2025 T-cell large granular lymphocyte leukemia Abcuro, Inc. Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06450886 Oct 2024 → Jan 2029 expected inclusion body myositis Abcuro, Inc. Active not recruiting No outcome recorded
Comparator or background therapy1 trial
Phase 2/3 NCT05721573 Comparator Feb 2023 → Nov 2025 inclusion body myositis Abcuro, Inc. Completed No outcome recorded

News releases announcing trial results or a regulatory action · 6

DateIssuerRelease
2026-03-26 Abcuro, Inc. Results Abcuro Presents Results from Phase 2/3 MUSCLE Study of Ulviprubart in Patients with Inclusion Body Myositis at GCOM 2026 abcuro.com ↗
Ulviprubart demonstrated a favorable safety and tolerability profile compared with placebo in the study
2026-02-24 Abcuro, Inc. Results Abcuro Announces Topline Results from the MUSCLE Study of Ulviprubart in Patients with Inclusion Body Myositis abcuro.com ↗
The MUSCLE study did not meet its primary endpoint, assessed by the IBM Functional Rating Scale (IBMFRS) total score at Week 76 compared to placebo, or key secondary endpoints.
2025-12-08 Abcuro, Inc. Results Abcuro Presents Interim Phase 1 Data Evaluating Ulviprubart in Patients with T Cell Large Granular Lymphocytic Leukemia at the 67th American Society of Hematology Annual Meeting abcuro.com ↗
2022-06-07 Abcuro, Inc. Results Abcuro Presents Additional Data from Ongoing Phase 1 Clinical Trial of ABC008 in Inclusion Body Myositis (IBM) at GCOM 2022 abcuro.com ↗
The additional data finds that ABC008 demonstrates proof-of-mechanism for depleting highly cytotoxic T cells, which attack and destroy muscle tissue in IBM.
2021-11-05 Abcuro, Inc. Results Abcuro to Present Late-Breaking Abstract at American College of Rheumatology Convergence 2021 of ABC008 Inclusion Body Myositis Phase 1 Data Demonstrating Proof of Mechanism for Selective Depletion of Highly Cytotoxic T Cells abcuro.com ↗
In the first cohort of individuals with IBM, selective and sustained depletion of highly cytotoxic T cells coincided with early signals of functional improvement.
2020-06-09 Abcuro, Inc. Regulatory Abcuro Granted Orphan Drug Designation for ABC008 for Inclusion Body Myositis abcuro.com ↗

All press releases naming this drug 13 releases

DateIssuerRelease

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Ulviprubart ClinicalTrials.gov intervention name — accepted as the source's own label NCT06450886 ↗
Known as ABC008 “Ulviprubart (ABC008)” NCT06450886 ↗
3

NCT04659031 ↗

NCT05721573 ↗

NCT05532722 ↗

Action Deplete “evaluate the recovery of the depletion of killer cell lectin-like receptor G1 (KLRG1)+ cells after the end of treatment with ABC008” NCT05721573 ↗
Modality Monoclonal antibody — CHEMBL4650433 ↗
Route Subcutaneous “Given subcutaneous injection” NCT05532722 ↗