Drugs / Actovegin
last change Aug 2019 re-read 2 minutes ago

Actovegin

Protein / enzyme biologic

Developed for
diabetic polyneuropathy · peripheral arterial occlusive disease 1 · cognitive disorder
Investigated by
Nycomed · Takeda

Trials 2 · a red edge is where a trial was stopped

200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT03469349 May 2018 → May 2019 peripheral arterial occlusive disease 1 Takeda Completed No outcome recorded
Phase 3 NCT00483730 Dec 2006 → May 2008 diabetic polyneuropathy Nycomed Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03543917 Background Aug 2017 → Aug 2018 stroke disorder Fundatia Bio-Forum Completed No outcome recorded
Phase 31 trial
Phase 3 NCT01582854 Comparator Jun 2012 → Nov 2014 cognitive disorder Takeda Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Actovegin “Intravenous administration of Actovegin, vitamins B1, B6, B12, C, oxytocin/dexamethasone, calcium gluconate, etc in 250 ml normal saline administered during approximately 2 hours” NCT03543917
3

NCT03469349

NCT00483730

NCT01582854

Modality Protein / enzyme biologic “Actovegin (a deproteinized hemoderivative of calf blood, 2000 mg/d for ≤20 intravenous infusions followed by 1200 mg/d orally)” PMID 28432265 May 2017
Route Intravenous “250 ml i.v. infusions once daily for 20 days followed by oral treatment 600 mg × 3 daily for 140 days.” NCT00483730
Route Oral “250 ml i.v. infusions once daily for 20 days followed by oral treatment 600 mg × 3 daily for 140 days.” NCT00483730