Drugs / Nimacimab
last change Aug 2024 re-read 2 minutes ago

Nimacimab

also known as JNJ-2463 · RYI-018

Monoclonal antibody targets CNR1 via inhibition

Developed for
fatty liver disease · gastroparesis · obesity disorder
Investigated by
Bird Rock Bio, Inc. · Perspectum · ProSciento, Inc. · Skye Bioscience, Inc.

Trials 3 · a red edge is where a trial was stopped

2018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03261739 Aug 2017 → Aug 2018 fatty liver disease Bird Rock Bio, Inc. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06577090 Aug 2024 → Nov 2026 expected obesity disorder Skye Bioscience, Inc. Active not recruiting No outcome recorded
Phase 2 NCT03900325 Aug 2019 → Jan 2020 gastroparesis Bird Rock Bio, Inc. Unknown No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as Nimacimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT03900325
1

NCT06577090

Known as JNJ-2463 ChEMBL registry synonym — accepted as the source's own label CHEMBL4298095
Known as RYI-018 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03261739
Action Inhibit “Cannabinoid CB1 receptor negative allosteric modulator” CHEMBL4298095
Modality Monoclonal antibody “Anti-CB1 monoclonal antibodyNCT03261739
1

CHEMBL4298095

Route Intravenous “repeat IV doses of RYI-018” NCT03261739
Target CNR1 “Cannabinoid CB1 receptor negative allosteric modulator” CHEMBL4298095