Drugs / ESBA105
last change Feb 2012 re-read 3 minutes ago

ESBA105

Monoclonal antibody targets TNF via inhibition

Developed for
anterior uveitis · cataract · dry eye syndrome
Investigated by
ESBATech AG · Alcon Research

Trials 4

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00671619 Apr → Jul 2008 — ESBATech AG Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00820014 Jan 2009 → Sep 2010 cataract ESBATech AG Completed No outcome recorded
Phase 22 trials
Phase 2 NCT01338610 Jun 2011 → Feb 2012 dry eye syndrome Alcon Research Completed No outcome recorded
Phase 2 NCT00823173 Jan 2009 → Dec 2010 anterior uveitis ESBATech AG Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as ESBA105 “ESBA105 is a topically administered tumour necrosis factor alpha (TNF-alpha) inhibitor that has significant therapeutic potential in various inflammatory intraocular diseases.” NCT00820014 ↗
3

NCT01338610 ↗

NCT00823173 ↗

NCT00671619 ↗

Action Inhibit “tumour necrosis factor alpha (TNF-alpha) inhibitor” NCT00820014 ↗
Modality Monoclonal antibody “anti TNF single chain antibody fragment” NCT00671619 ↗
Route Topical “ESBA105 administered topically to the eye” NCT00671619 ↗
Target TNF “anti TNF single chain antibody fragment” NCT00671619 ↗