Drugs / Deleobuvir
last change Nov 2016 re-read 2 minutes ago

Deleobuvir

Small molecule

Developed for
chronic hepatitis C virus infection
Investigated by
Boehringer Ingelheim

Trials 19 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 113 trials
Phase 1 NCT01983566 Nov 2013 → Jan 2014 Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT01941615 Nov 2013 → Jan 2014 Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT01965431 Oct 2013 → Jan 2014 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT01957657 Oct → Dec 2013 impaired renal function disease Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT01737996 Nov 2012 → Mar 2013 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT01605461 May → Jun 2012 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT01525628 Apr 2012 → Dec 2013 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT01347086 May → Jun 2011 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02182401 Jul → Aug 2009 Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT02182414 May → Sep 2009 Boehringer Ingelheim Completed No outcome recorded
Phase 23 trials
Phase 2 NCT01830127 Apr 2013 → Oct 2014 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT01528735 Feb 2012 → Aug 2013 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT01132313 May 2010 → Oct 2014 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Phase 33 trials
Phase 3 NCT01858961 May 2013 → Jul 2016 chronic hepatitis C virus infection Boehringer Ingelheim Withdrawn No outcome recorded
Phase 3 NCT01732796 Dec 2012 → Jan 2015 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT01728324 Nov 2012 → Feb 2014 chronic hepatitis C virus infection Boehringer Ingelheim Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01535638 Comparator Feb → Mar 2012 Boehringer Ingelheim Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01859962 Comparator May 2013 → May 2014 chronic hepatitis C virus infection Presidio Pharmaceuticals, Inc. Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 23 sources stand behind the page.

FieldValueCited text
Known as deleobuvir “HCVerso1 and 2: faldaprevir with deleobuvir (BI 207127) and ribavirin for treatment-naïve patients with chronic hepatitis C virus genotype-1b infection.” PMID 27920566 Nov 2016
3

“Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection.” PMID 23558093 Apr 2013

“faldaprevir with deleobuvir (BI 207127) and ribavirin” PMID 27920566 Nov 2016

“BI 207127 (Deleobuvir)” NCT01965431

Known as BI 207127 “Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection.” PMID 23558093 Apr 2013
16

“faldaprevir with deleobuvir (BI 207127) and ribavirin” PMID 27920566 Nov 2016

NCT01957657

NCT01983566

NCT01535638

NCT00905632

NCT01858961

NCT01941615

NCT01728324

NCT01965431

NCT02176525

NCT01830127

NCT01859962

NCT02182414

NCT01525628

NCT01605461

NCT01737996

Known as BI 207127 NA “Single oral solution dose of BI 207127 NA combined with \[14C\]-BI 207127 NA” NCT01605461
5

“Drug: BI 207127 NANCT02176525

NCT02182401

NCT02182388

NCT01347086

NCT01528735

Known as BI-207127 SODIUM SALT ChEMBL registry synonym — accepted as the source's own label CHEMBL2403318
Known as DELEOBUVIR SODIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL2403318
Action Inhibit “BI 207127 is a potent non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor in vitro.” PMID 22414766 Mar 2012
Modality Small molecule “BI 207127 is a potent non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor in vitro.” PMID 22414766 Mar 2012
Route Oral “Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1” PMID 23558093 Apr 2013