Drugs / Dordaviprone
Dordaviprone
also known as
ONC201 · Dordaviprona · Dordaviprone dihydrochloride · DORDAVIPRONE HYDROCHLORIDE · NSC-350625 · ONC-201 DIHYDROCHLORIDE · ONC201 hydrochloride · TIC10 · +1 more
Small molecule targets CLPP, DRD2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | MODEYSO | — | 2025-08-06 | fda.gov ↗ |
Trials 29 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| — | NCT04617002 Background | — | diffuse midline glioma, H3 K27M-mutant | Jazz Pharmaceuticals | Approved for marketing | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 33 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | dordaviprone | “ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma.” PMID 38335473 ↗ Feb 20248“ONC201 (dordaviprone) is a ClpP agonist and DRD2 antagonist.” NCT04617002 ↗ “Dordaviprone (ONC201)” NCT05476939 ↗ |
| Known as | Dordaviprona | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | Dordaviprone dihydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | DORDAVIPRONE HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | NSC-350625 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | ONC-201 DIHYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | ONC201 | “The purpose of this phase I trial is to test the safety and cancer preventive effects of different doses of ONC201 in people with familial adenomatous polyposis (FAP) or a...” NCT05630794 ↗29“Dordaviprone (ONC201) is a brain-penetrant, small-molecule imipridone that acts as a mitochondrial caseinolytic protease P (ClpP) agonist and a dopamine receptor D2 (DRD2) antagonist.” NCT02525692 ↗ “This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in recurrent H3 K27M-mutant DMG.” PMID 38335473 ↗ Feb 2024 “Dordaviprone (ONC201)” NCT05580562 ↗ “Dordaviprone (ONC201)” NCT03485729 ↗ “Dordaviprone (ONC201)” NCT03416530 ↗ |
| Known as | ONC201 hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Known as | TIC10 | “ONC201 (TIC10) is a first-in-class small molecule” NCT02038699 ↗ |
| Known as | TIC10 hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297310 ↗ |
| Action | Inhibit | “small molecule antagonist of DRD2” PMID 31118108 ↗ May 2019 |
| Modality | Small molecule | “ONC201 (TIC10) is a first-in-class small molecule” NCT02038699 ↗ |
| Route | Oral | “ONC201 capsules will be administered orally” NCT02038699 ↗ |
| Target | DRD2 | “ONC201 is a small molecule antagonist of DRD2” PMID 31118108 ↗ May 2019 |