Effective and safe transfer of maternal antibodies persisting two months postpartum following maternal immunization with different doses of recombinant pertussis-containing vaccines

Highlights • Recombinant pertussis vaccine is safe for both mother and newborn. • There is effective transplacental antibody transfer to infants at birth. • No difference in antibody response is shown during 2nd or 3rd trimester of pregnancy. Abstract Introduction Recombinant acellular pertussis (ap) vaccines containing genetically inactivated pertussis toxin (PTgen) and filamentous hemagglutinin (FHA) with or without tetanus (TT) and diphtheria (DT) vaccines (Td) were found safe and immunogenic in non-pregnant and pregnant women. We report here maternal antibody transfer and safety data in mothers and neonates. Methods This is the follow up of a phase 2 trial in 2019 among 400 pregnant women who randomly received one dose of recombinant pertussis-only vaccine containing 1 µg PTgen and 1 µg FHA (ap1gen), or Td combined with ap1gen (Tdap1gen), or with 2 µg PTgen and 5 µg FHA (Tdap2gen), or with 5 µg PTgen and 5 µg FHA (TdaP5gen, Boostagen®, BioNet, Thailand) or chemically-inactivated acellular pertussis comparator (Tdap8chem, Boostrix™, GSK, Belgium), either in the second or third trimester of gestation. IgG against PT, FHA, TT and DT were assessed by ELISA, PT-neutralizing antibodies (PTNA) by Chinese Hamster Ovary cell assay and safety outcomes at delivery in mothers and at birth. Results Anti-PT and anti-FHA geometric mean concentration (GMC) ratio between infants at birth and mothers at delivery was above 1 in all groups. PT GMC in infants at birth were ≥30 IU/mL in all groups with the highest titers in infants found in TdaP5gen group at birth (118.8 [95% CI 93.9–150.4]). At 2 months, PT GMC ratio to Tdap8chem (98.75% CI) was significantly higher for TdaP5gen (2.6 [1.7–4.0]) and comparable for other recombinant vaccines. No difference in PTNA titers at birth was observed between all groups nor between time of vaccination. Adverse events were comparable in all vaccine groups. Conclusions BioNet licensed (TdaP5gen and Tdap2gen) and candidate vaccines (Tdap1gen and ap1gen) when given to pregnant women in the second or third trimester of gestation are safe and have induced passive pertussis immunity to infants. Read a full publication at The Vaccine Journal Search News categories BioNet News (29) Events (8) Biotech News (60) Thailand (2) Covid-19 (2) News tags Acellular Pertussis Vaccine (5) Adolescent (3) AI (3) aP (5) Artificial Intelligence (5) biotechnology (12) booster vaccine (3) Bordetella pertussis (9) cancer (8) Cancer vaccine (5) covid-19 (22) COVID-19 vaccine (3) Diphtheria (7) DNA (3) Flu (3) genetically detoxified pertussis toxin (6) Immune Response (8) immune system (12) Immunization (5) immunoginicity (5) infectious disease (4) infectious diseases (4) maternal immunization (3) mRNA (14) mRNA Technology (7) pandemic (8) Pertussis (9) Pertussis Toxin (4) pertussis vaccine (5) PT (5) PTgen (5) respiratory diseases (4) RNA (4) SARS-CoV-2 (8) Tdap (8) tetanus (6) Tuberculosis (3) vaccination (10) vaccine (35) Vaccine Development (10) vaccines (4) Vaccine Storage (3) virus (3) Whooping Cough (8) Whoopingcough (4) Recent News Hybrid Nanocarriers Could Enable Targeted Vaccine Delivery in the Lungs January 22, 2026 The golden age of vaccine development January 19, 2026 The European Commission Grants Marketing Authorisation for a First-of-its-Kind Pertussis-Only Vaccine for Vaccination of Teenagers, Adults and Pregnant Women in the European Union January 15, 2026 New Pertussis Vaccine Set for Implementation December 20, 2025 BioNet Receives Positive CHMP Opinion from EMA for VacPertagen, a Recombinant Vaccine Against Pertussis November 21, 2025 Subscribe Terms of use Privacy 2026© BioNet-Asia. All rights reserved. We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.Ok

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