VOLUNTARY ANNOUNCEMENT - SYS6005 (ANTIBODY-DRUG CONJUGATE) OBTAINS CLINICAL TRIAL APPROVAL

Hong Kong Exchanges and Clearing Limited and The Stock Excha nge of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoe ver for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this ann ouncement. CSPC PHARMACEUTICAL GROUP LIMITED (Incorporated in Hong Kong with limited liability) (Stock Code: 1093) ʮ ̡ VOLUNTARY ANNOUNCEMENT SYS6005 (ANTIBODY-DRUG CONJUGATE) OBTAINS CLINICAL TRIAL APPROVAL The board of directors (the ‘‘Board ’’) of CSPC Pharmaceutical Group Limited (the ‘‘Company ’’, together with its subsidiaries, the ‘‘Group ’’) is pleased to announce that SYS6005 (Antibody-Drug Conjugate) (the ‘‘Product ’’) developed by the Group has obtained clinical trial approva l granted by the National Medical Products Administration of the People ’s Republic of China to conduct clinical trials in China. The Product is a monoclonal antibody-drug conjugate which c an bind to specific receptors on the tumor surface and achieve tumor cell killing by entering the cells through endocytosis and releasing toxins. The Product is applied as a Class 1 therapeutic biological pr oduct. The approved indication is advanced tumors, and is expected to be indicated for the treatment of h ematologic tumors, ovarian cancer and non-small cell lung cancer. Preclinical studies demonstra ted that the Product had good anti-tumor effects on a variety of cancers, providing a promising prosp ect of demonstrating good efficacy in subsequent clinical trials. A number of patent application s of the Product have been submitted in China and overseas. By order of the Board CSPC Pharmaceutical Group Limited CAI Dongchen Chairman Hong Kong, 20 December 2024 As at the date of this announcement, the Board comprises Mr. C AI Dongchen, Mr. ZHANG Cuilong, Mr. WANG Zhenguo, Mr. PAN Weidong, Mr. WANG Huaiyu, Dr. LI Chu nlei, Dr. YAO Bing, Mr. CAI Xin and Mr. CHEN Weiping as executive directors; and Mr. WANG Bo, Mr. CHEN Chuan, Prof. WANG Hongguang, Mr. AU Chun Kwok Alan, Mr. LAW Cheuk Kin Steph en and Ms. LI Quan as independent non-executive directors.

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