Aligos Therapeutics Announces Eight Abstracts Accepted at The Liver Meeting® 2025

Oral presentation will include the full 96-week and post-treatment follow up data from the Phase 1 monotherapy study of ALG-000184 SOUTH SAN FRANCISCO, Calif., Oct. 07, 2025 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on improving patient outcomes through best-in-class therapies for liver and viral diseases, today announced eight presentations, including one oral presentation, at The Liver Meeting® 2025, being held November 7 – 11, 2025 in Washington, D.C. The abstracts released today can be found on the AASLD website at https://www.aasld.org/the-liver-meeting. Details on the abstracts are as follows: ALG-000184: Potential first-/best-in-class small molecule CAM-E for chronic hepatitis B virus (HBV) infection Publication #: 0198 Type: Oral Presentation Title: Oral Once -Daily 300 mg ALG-000184, a Novel Capsid Assembly Modulator Demonstrates potent suppression of HBV DNA in Treatment-Naive or Currently-not-treated Subjects with Chronic HBV Presenter: Professor Man-Fung Yuen, MBBS, MD, PhD, DSc, Chair and Chief of the Division of Gastroenterology and Hepatology, University of Hong Kong Date/Time: November 9, 2025 at 5:00pm – 6:30pm ET Session: Next-generation HBV Therapeutics: Emerging Therapies and Search for Functional Cure Publication #: 1208 Type: Poster Presentation Title: Sustained Reduction of HBV Antigen Levels During the 8-Week Follow-up Period in Treatment Naïve (TN) or Currently-Not-Treated (CNT) HBeAg-Positive Subjects with Chronic Hepatitis B Virus Infection After 96-Week 300 mg ALG-000184 Presenter: Professor Man-Fung Yuen, MBBS, MD, PhD, DSc, Chair and Chief of the Division of Gastroenterology and Hepatology, University of Hong Kong Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”) Publication #: 1251 Type: Poster Presentation Title: Capsid Assembly Modulator ALG-001075 Prevents cccDNA Formation and HBV DNA Integration In Vitro Presenter: Jordi Verheyen Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”)  Publication #: 1338 Type: Poster Presentation Title: Capsid Assembly Modulator ALG-001075 Binds and Directly Targets HBeAg Presenter: Jordi Verheyen Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”) Preclinical Publication #: 1248 Type: Poster Presentation Title: Differentiation of HBV capsid assembly modulators based on stabilization of core protein oligomerization and residence time Presenter: Cheng Liu, PhD Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”) Publication #: 1330 Type: Poster Presentation Title: CAM-E and CAM-A Compounds Differentially Affect Phosphorylated and Non-Phosphorylated Hepatitis B Core Protein In Vitro Presenter: Rene Geissler, PhD, Abbott Diagnostics Division Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”) Publication #: 1155 Type: Poster Presentation Title: Lead Optimization and Selection of a Potential Best-in-Class HBV ASO Presenter: Jin Hong, PhD Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: Hepatitis B (“1118-1367”) Publication #: 1103 Type: Poster Presentation Title: Two Pre-clinical Short Interfering RNA Molecules Targeting Human HSD17beta13 for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis Presenter: Jieun Song, PhD Date/Time: November 7, 2025 at 8:00am – 5:00pm ET Session: MASLD/MASH - Experimental: Basic ("1001-1117") About Aligos Aligos Therapeutics, Inc. (NASDAQ: ALGS) is a clinical stage biotechnology company founded with the mission to improve patient outcomes by developing best-in-class therapies for the treatment of liver and viral diseases. Aligos applies its science driven approach and deep R&D expertise to advance its purpose-built pipeline of therapeutics for high unmet medical needs such as chronic hepatitis B virus (HBV) infection, metabolic dysfunction-associated steatohepatitis (MASH), and coronaviruses. For more information, please visit www.aligos.com or follow us on LinkedIn or X. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered “forward-looking statements,” including without limitation, statements regarding Aligos’ financial results and performance as well as research and development activities, including regulatory status and the timing of announcements and updates relating to our regulatory filings and clinical trials. Such forward looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance, or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties inherent in the drug development process, including Aligos’ clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, and other matters that could affect the sufficiency of Aligos’ capital resources to fund operations. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos’ Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2025 and its future periodic reports to be filed or submitted with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events. Investor Contact Aligos Therapeutics, Inc. Jordyn Tarazi Vice President, Investor Relations & Corporate Communications +1 (650) 910-0427 [email protected] Media Contact Inizio Evoke Jake Robison Vice President [email protected]

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