Bicycle Therapeutics to Present BT5528 Interim Phase I Data at AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics

- Company to host conference call on Thursday, October 7, 2021 at 3:00 p.m. ET CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)--Sep. 30, 2021-- Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced that interim Phase I results from its Phase I/II trial of BT5528, a second-generation Bicycle® Toxin Conjugate (BTC™) targeting EphA2, has been selected for a plenary oral presentation at the upcoming AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, being held October 7-10, 2021. The Company will host a conference call to discuss the results and provide an update on preliminary findings from the BT8009 program on Thursday, October 7, 2021 at 3:00 p.m. ET. AACR-NCI-EORTC Plenary Oral Presentation Details: Title: A first in class phase I/II Study of the Novel Bicyclic Peptide and MMAE Conjugate, BT5528, in patients with Advanced Malignancies Associated with EphA2 Expression Presenter: Meredith McKean, M.D., Sarah Cannon Research Institute at Tennessee Oncology Session Title: Tumor-targeted Conjugates: A Growing Family Date/Time: Thursday, October 7 at 12:50 p.m. ET Conference Call Details Bicycle Therapeutics will host a conference call and webcast on Thursday, October 7 at 3:00 p.m. ET to review the data being presented and provide an update on preliminary findings from the BT8009 program. To access the call, please dial (800) 377-9118 (domestic) or (409) 937-8920 (international) and provide the Conference ID 2287246. A live webcast of the presentation will be available on the Investors & Media section of the Bicycle website, bicycletherapeutics.com. About Bicycle Therapeutics Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC™) targeting EphA2, and BT8009, a second-generation BTC™ targeting Nectin-4, a well-validated tumor antigen, in company-sponsored Phase I/II trials. In addition, BT1718, a BTC™ that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial sponsored by the Centre for Drug Development of Cancer Research UK. Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, MA. For more information, visit bicycletherapeutics.com. View source version on businesswire.com: https://www.businesswire.com/news/home/20210930005667/en/ Investors: David Borah, CFA VP, Capital Markets & Investor Relations [email protected] 617-203-8300 Media: Consilium Strategic Communications Sukaina Virji or Mary-Jane Elliott [email protected] Source: Bicycle Therapeutics plc Press Releases Close IR Nav Overview →Stock Information →SEC Filings →Annual General Meeting →UK Annual Reports →Governance + Leadership →Presentation + Events →Analyst Coverage →Press Releases →Investor Resources → IR Nav Overview Stock Information SEC Filings Annual General Meeting UK Annual Reports Governance + Leadership Presentation + Events Analyst Coverage Press Releases Investor Resources United Kingdom Blocks A & B Portway Building Granta Park Great Abington Cambridge CB21 6GP View Google Map United States 4 Hartwell Place Lexington, MA 02421 View Google Map General Enquiries [email protected] Follow LinkedIn Twitter Privacy © Bicycle Therapeutics 2026 Designed by Greenspace Sign up Search Close Search Search → Hello We use cookies and other technologies to optimise your experience and analyse our traffic. Please confirm you are happy to accept. You can change your preferences in Cookie Settings. Find out more Accept var s_CCSWebHostingAccount = "trcgbicycle"; {"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/8091","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en","themeUrl":"sites\/g\/files\/knoqqb78741\/themes\/site\/nir_pid3307"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJyNkdFuQyEIhl-oOTbpxR6HoLLWHYUToNv69rW6pO2yZYsXCn7y8yMXBWSsFy_JAj9GC2aJBBXPnE47_hPcVPLAIhoNoiRhe065SI2oI5lWysVFIaP3FStZuB-XVxV24lmzoa7kg4RYJa1hyJuDohc-doVe8ITq_8INhsgvbCNkUErSWtfvD4Qfa5-rl9Zbx_AcjtsNj9Pp7bDgG34C5gypohlgJXX7gUvDqoNdOHUrzDRHtJV8OOxfgryTasmz4Q-KVpyApU-f5md8yy1f-866Z2rhNv8rJ2XCOg","theme":"nir_pid3307","theme_token":null},"ajaxTrustedUrl":[],"nir_admin_use_chosen":true,"nir_admin_use_select2":false,"user":{"uid":0,"permissionsHash":"364a63fdd1ba8bf28808b7d4a735dfbd500f3bdd6295cc883846cac82cce7d97"}}

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