Brii Bio to Present Cross-Study Analysis of Post-Treatment HBsAg Rebound at APASL 2026

DURHAM, N.C. and BEIJING, China – April 15 , 202 6 – Brii Biosciences Limited (“Brii Bio,” “Brii,” or the “Company,” stock code: 2137.HK), a biotechnology company developing therapies to improve patient health and choice across diseases with high unmet medical need, today announced that it will present a pooled cross-study analysis of post-end-of-treatment (EOT) hepatitis B surface antigen (HBsAg) rebound in participants with chronic hepatitis B virus (HBV) infection from the Phase 2 ENSURE and BRII-179-002 studies. The data will be presented at the 35 th Annual Meeting of the Asian Pacific Association for the Study of the Liver (APASL 2026), taking place from April 22-25, 2026 in Istanbul, Turkey. Additional details of the oral presentation are as follows: Title: Cross-study Analysis of HBsAg Rebound Following Treatments of Elebsiran/BRII-179 in Combination with Peginterferon Alfa Session/Presentation Type: Oral Presentation Session 58 Date and time: 13:40 - 15:10 on April 25 (UTC+3) Presenter: Jidong Jia, M.D., Ph.D., Professor of Medicine at the Liver Research Centre, Beijing Friendship Hospital, Capital Medical University in Beijing, China For more information about Brii Bio’s HBV candidates visit www.briibio.com . About Hepatitis B Hepatitis B virus (HBV) infection is one of the world’s most significant infectious disease threats with more than 254 million people infected globally. 1 Chronic HBV infection is the leading cause of liver disease and an estimated 820,000 people die of complications from chronic HBV infection each year. 1 HBV is of exceptional concern in China, where 87 million people are chronically infected. 2 About BRII-179 BRII-179 is a novel recombinant protein-based HBV immunotherapeutic candidate that expresses the Pre-S1, Pre-S2, and S HBV surface antigens, and is designed to induce enhanced and broad B-cell and T-cell immunity. In November 2023, the Center for Drug Evaluation (the “CDE”) of the National Medical Products Administration (the “NMPA”) granted BRII-179 Breakthrough Therapy Designation. About Elebsiran Elebsiran is an investigational subcutaneously administered HBV-targeting siRNA designed to degrade hepatitis B virus RNA transcripts and limit the production of hepatitis B surface antigen. It has the potential to have direct antiviral activity against HBV and HDV. It is the first siRNA in the clinic to include Enhanced Stabilization Chemistry Plus technology to enhance stability and minimize off-target activity, which potentially can result in an increased therapeutic index. Brii Bio licensed exclusive rights to develop and commercialize elebsiran for the Greater China territory from Vir Biotechnology, Inc. in 2020. In May 2024, the CDE of the NMPA granted elebsiran Breakthrough Therapy Designation. About Brii Bio Brii Biosciences Limited (“Brii Bio,” stock code: 2137.HK) is a biotechnology company developing therapies to improve patients’ health by addressing high unmet medical needs with limited treatment options. The Company is advancing a broad pipeline of unique therapeutic candidates with lead programs against hepatitis B virus (HBV) infection. The Company is led by a visionary and experienced leadership team and has operations in both China and the United States. For more information, visit www.briibio.com . Media Inquiries: [email protected] Investor Inquiries: [email protected] Partnering Inquiry: [email protected] ------------------------------------------------------- 1 World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https://www.who.int/publications/i/item/9789240091672 2 World Health Organization. Hepatitis. World Health Organization. Retrieved from https://www.who.int/china/health-topics/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C. 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