HiberCell to Present Preclinical Data from Novel GCN2 Activator and PERK Inhibitor Programs at The Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting

class="post-content padded"> NEW YORK, Nov. 02, 2022 (GLOBE NEWSWIRE) — HiberCell, a clinical-stage biotechnology company developing therapeutics to address therapeutic resistance, cancer relapse and metastasis, today announced two clinical abstract poster presentations at the upcoming Society for Immunotherapy of Cancer (SITC) 37 th Annual Meeting taking place November 8-12, 2022 in Boston, MA. Poster Presentations: Abstract Title: Novel GCN2 modulator HC-7366 decreases pulmonary metastases and reduces myeloid-derived suppressor cells Poster/Abstract Number: 1327 Presenting Author(s): Jeremy Drees, PhD Poster Reception Date/Time: 11/10/2022 – 7:30 – 9:00pm Poster Hall at Boston Convention and Exhibition Center 415 Summer Street Boston, MA 02210 Abstract Title: PERK inhibitor HC-5404 demonstrates immune-activation and anti-tumor efficacy in combination with anti-PD1 immune checkpoint inhibitor antibody Poster/Abstract Number: 884 Presenting Author(s): _Anissa Chan, PhD Poster Reception Date/Time: 11/11/2022 – 7:00 – 8:30pm Poster Hall at Boston Convention and Exhibition Center 415 Summer Street Boston, MA 02210 Full text of the abstracts will be available on the SITC website at 8:00 a.m. ET on November 7, 2022. The posters will present the immunomodulatory mechanisms of HC-7366, a differentiated selective, orally bioavailable activator of GCN2 (general controlled nonderepressible 2), and HC-5404, a differentiated highly selective, orally bioavailable inhibitor of key stress response protein kinase PERK (protein kinase RNA-like endoplasmic reticulum kinase). GCN2 is one of the central kinases in the integrated stress response (ISR) that responds to amino acid deprivation and is a key metabolic stress sensor in cells. PERK is part of the unfolded protein response (UPR) that is activated in cancer cells by accumulation of misfolded proteins in the ER and enables their adaptive survival mechanism. HiberCell is currently conducting Phase 1 clinical trials in solid tumors for each of our therapeutic candidates HC-7366 (NCT05121948) and HC-5404 (NCT04834778). About HiberCell HiberCell is a clinical-stage biotechnology company dedicated to the advancement of novel therapeutic agents targeting adaptive stress pathways and immune modulation to enable patients to live longer, cancer-free lives. HiberCell’s pipeline of therapeutic candidates seeks to address the mechanisms of treatment resistance, cancer relapse and metastasis, which account for an estimated 90% of all cancer-related deaths. HiberCell utilizes artificial intelligence and machine learning to integrate multi-omic and phenotypic profiles of tumors to generate insights that connect this information to clinical outcomes. Contact: Christina Tartaglia Stern Investor Relations, Inc. 212.362.1200 [email protected]

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