Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand

A new generation of recombinant acellular pertussis vaccine containing genetically inactivated pertussis toxin (PTgen) was licensed as a monovalent pertussis vaccine (aPgen; Pertagen®) and in combination with tetanus and reduced-dose diphtheria (TdaPgen; Boostagen®) for active immunization in individuals aged 11 years and older in Thailand in 2016. We here report post-marketing safety data on the use of the vaccines in individuals in the community obtained through active pharmacovigilance surveillance including pregnant women participating in a prospective observational study. Between May 2017 and February 2020 for TdaPgen and between June 2018 and February 2020 for aPgen, participating health care providers vaccinated and collected safety data for 11,429 exposed adolescents and adults. This included 1778 pregnant women. The incidence rate of adverse events following immunization (AEFIs) was 11.5 per 1000 of vaccinated individuals (95% confidence interval (95% CI) 9.7–13.6). AEFIs mostly concerned local pain at the injection site and muscle pain, and symptoms were mild and mostly resolved within a few days with no complications. The incidence rate of AEFIs in women vaccinated during pregnancy was 1.1 per 1000 (95% CI 0.3–4.1). Of 833 pregnant women vaccinated with recombinant aPgen or TdaPgen, 91.4% (95% CI 89.3–93.3) had uncomplicated pregnancies and 98.7% (95% CI 97.7–99.4) of the 855 babies delivered by these women were born healthy, which exceeds rates generally reported in Thailand. There were no vaccine-related serious adverse events reported during the surveillance period. In conclusion, active pharmacovigilance confirms that the recombinant pertussis vaccines aPgen (Pertagen) and TdaPgen (Boostagen) are safe in adolescents and adults, including pregnant women vaccinated in the second or third trimester of pregnancy. Source: ScienceDirect Acellular Pertussis Vaccine, Adolescent, aP, Diphtheria, genetically detoxified pertussis toxin, immunoginicity, Pertussis, recombinant pertussis, Tdap, tetanus, Thailand, vaccination, vaccine Search News categories BioNet News (29) Events (8) Biotech News (60) Thailand (2) Covid-19 (2) News tags Acellular Pertussis Vaccine (5) Adolescent (3) AI (3) aP (5) Artificial Intelligence (5) biotechnology (12) booster vaccine (3) Bordetella pertussis (9) cancer (8) Cancer vaccine (5) covid-19 (22) COVID-19 vaccine (3) Diphtheria (7) DNA (3) Flu (3) genetically detoxified pertussis toxin (6) Immune Response (8) immune system (12) Immunization (5) immunoginicity (5) infectious disease (4) infectious diseases (4) maternal immunization (3) mRNA (14) mRNA Technology (7) pandemic (8) Pertussis (9) Pertussis Toxin (4) pertussis vaccine (5) PT (5) PTgen (5) respiratory diseases (4) RNA (4) SARS-CoV-2 (8) Tdap (8) tetanus (6) Tuberculosis (3) vaccination (10) vaccine (35) Vaccine Development (10) vaccines (4) Vaccine Storage (3) virus (3) Whooping Cough (8) Whoopingcough (4) Recent News Hybrid Nanocarriers Could Enable Targeted Vaccine Delivery in the Lungs January 22, 2026 The golden age of vaccine development January 19, 2026 The European Commission Grants Marketing Authorisation for a First-of-its-Kind Pertussis-Only Vaccine for Vaccination of Teenagers, Adults and Pregnant Women in the European Union January 15, 2026 New Pertussis Vaccine Set for Implementation December 20, 2025 BioNet Receives Positive CHMP Opinion from EMA for VacPertagen, a Recombinant Vaccine Against Pertussis November 21, 2025 Subscribe Terms of use Privacy 2026© BioNet-Asia. All rights reserved. We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.Ok

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