Shattuck Labs to Host Investor Call and Webcast on Phase 1 Clinical Data of SL-325, a Potentially First-in-Class DR3 Blocking Antibody, and Pipeline Update on June 8

AUSTIN, Texas and DURHAM, N.C., June 05, 2026 (GLOBE NEWSWIRE) -- Shattuck Labs, Inc. (Shattuck) (NASDAQ: STTK), a clinical-stage biotechnology company pioneering the development of potentially first-in-class monoclonal and bispecific DR3-blocking antibodies for the treatment of patients with inflammatory and immune-mediated diseases, today announced that it will host an investor call and webcast on Monday, June 8, 2026 at 8:00 a.m. ET to present comprehensive Phase 1 clinical data for SL-325, including safety, tolerability, pharmacokinetics, receptor occupancy, pharmacodynamic and immunogenicity results and provide a pipeline update. The event will feature presentations by members of Shattuck’s management team, including Taylor Schreiber, M.D., Ph.D., Chief Executive Officer, Lini Pandite, M.D., M.B.A., Chief Medical Officer, Suresh De Silva, Ph.D., Chief Scientific Officer, Michael Choi, M.D., Vice President of Clinical Development, and Andrew Neill, M.B.A., Chief Financial Officer, followed by a question-and-answer session. Conference Details Title : Phase 1 Clinical Data of SL-325, a Potentially First-in-Class DR3 Blocking Antibody, and Pipeline Update Date & Time: Monday, June 8, 2026 at 8:00 a.m. ET Webcast Details: Click here Interested parties can access the live webcast via the Events & Presentations section of the Company’s website at www.shattucklabs.com . A replay of the webcast will be available for approximately 30 days following the event. About SL-325 SL-325 is a potential first-in-class Death Receptor 3 (DR3) blocking antibody designed to achieve a complete and durable blockade of the clinically validated DR3/TL1A pathway. Shattuck’s preclinical studies demonstrate high affinity binding and superior activity over TL1A antibodies, and offer a data-driven rationale for targeting the TNF receptor, DR3, versus its ligand, TL1A. SL-325 is a fully Fc-silenced, fully human immunoglobulin G monoclonal antibody with a favorable safety profile in non-human primates, currently being evaluated in a Phase 1 clinical trial. About Shattuck Labs, Inc. Shattuck Labs, Inc. is a clinical-stage biotechnology company pioneering the development of potentially first-in-class monoclonal and bispecific DR3 blocking antibodies for the treatment of patients with inflammatory and immune-mediated diseases. Shattuck’s expertise in protein engineering and the development of novel TNF receptor therapeutics come together in its lead program, SL-325, a potentially first-in-class DR3 antagonist antibody designed to achieve a more complete blockade of the clinically validated DR3/TL1A pathway. The Company has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit: www.ShattuckLabs.com. Investor & Media Contact: Andrew R. Neill Chief Financial Officer Shattuck Labs, Inc. [email protected] Source: Shattuck Labs, Inc. 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text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl04_divModuleContainer .evergreen-link:hover { color: var(--evgLightColor); text-decoration: none; text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl04_divModuleContainer .evergreen-link:focus, .evergreen-link:focus-visible { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } Pipeline Pipeline opens in new window @media (max-width: 480px){ #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 481px) and (max-width: 1024px){ #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 1025px) { #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link { font-size: 14px; } } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer.evergreen { background: var(--evgBrand1Color); } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { text-align: left; color: var(--evgLightColor); line-height: 1; } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-item { background: var(--evgBrand1Color); border-bottom: 0 none; } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-item-title { } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link { } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link:not(:hover):not(:focus) { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link:hover { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl07_divModuleContainer .evergreen-link:focus, .evergreen-link:focus-visible { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } Investors Overview opens in new window News & Events opens in new window Stock Info opens in new window Financials opens in new window Governance opens in new window IR Resources opens in new window @media (max-width: 480px){ #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 481px) and (max-width: 1024px){ #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 1025px) { #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link { font-size: 14px; } } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer.evergreen { background: var(--evgBrand1Color); } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { text-align: left; color: var(--evgLightColor); line-height: 1; } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-item { background: var(--evgBrand1Color); border-bottom: 0 none; } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-item-title { } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link { } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link:not(:hover):not(:focus) { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link:hover { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl10_divModuleContainer .evergreen-link:focus, .evergreen-link:focus-visible { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } Careers Culture opens in new window Join Our Team opens in new window @media (max-width: 480px){ #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 481px) and (max-width: 1024px){ #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link { font-size: 14px; } } @media (min-width: 1025px) { #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { font-size: 20px; } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link { font-size: 14px; } } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer.evergreen { background: var(--evgBrand1Color); } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { text-align: left; color: var(--evgLightColor); line-height: 1; } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-item { background: var(--evgBrand1Color); border-bottom: 0 none; } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-item-title { } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link { } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link:not(:hover):not(:focus) { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link:hover { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } #_ctrl0_FooterPane_footer_pane_sec_ctl13_divModuleContainer .evergreen-link:focus, .evergreen-link:focus-visible { color: var(--evgLightColor); text-decoration-color: var(--evgLightColor); } Contact Contact opens in new window #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid-title { background-color: transparent; padding-top: 50px; padding-bottom: 0px; margin-bottom: -20px; } #evergreen_grid_footer_pane_secondary.evergreen-grid.evergreen-grid-wrapper { background-size: cover; background-position: center; background-repeat: no-repeat; position: relative; } #evergreen_grid_footer_pane_secondary.evergreen-grid.evergreen-grid-wrapper::after { position: absolute; content: ""; top: 0; left: 0; bottom: 0; right: 0; } #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid-container { border-top: none ; border-bottom: none ; position: relative; z-index: 1; } #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid-title, #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid-module { z-index: 1; } #evergreen_grid_footer_pane_secondary.evergreen-grid { --evergreenGridModulePaddingLeft: 0; --evergreenGridModulePaddingRight: 0; } #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid-module > .evergreen { padding-left: var(--evergreenGridModulePaddingLeft); padding-right: var(--evergreenGridModulePaddingRight); } #evergreen_grid_footer_pane_secondary.evergreen-grid .evergreen-grid.evergreen-grid-container { } @media (max-width: 480px){ #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-item-title { font-size: 10px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link { font-size: 12px; } } @media (min-width: 481px) and (max-width: 1024px){ #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-item-title { font-size: 10px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link { font-size: 12px; } } @media (min-width: 1025px) { #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-item-title { font-size: 10px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link { font-size: 12px; } } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer.evergreen { background: var(--evgBrand1Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-item { background: var(--evgBrand1Color); border-bottom: 0 none; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-item-title { } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link { text-transform: capitalize; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link:not(:hover):not(:focus) { color: var(--evgBrand3Color); text-decoration-color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link:hover { color: var(--evgBrand3Color); text-decoration: underline solid; text-decoration-color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl04_divModuleContainer .evergreen-link:focus, .evergreen-link:focus-visible { color: var(--evgBrand3Color); text-decoration: underline solid; text-decoration-color: var(--evgBrand3Color); } Privacy Policy opens in new window | Terms of Use opens in new window | Site Map opens in new window #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer.evergreen-wysiwyg { background-color: var(--evgBrand1Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { --alignment: center; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-item { --backgroundColor: var(--evgBrand1Color); } @media (min-width: 481px) and (max-width: 1024px) { #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { } } @media (max-width: 480px) { #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { } } #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-card-c { --border:none; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-card-c:hover { --border:none; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl07_divModuleContainer .evergreen-card-c:focus { --border:none; } @media (max-width: 480px){ #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title { font-size: 12px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link { font-size: 12px; } } @media (min-width: 481px) and (max-width: 1024px){ #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title { font-size: 12px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link { font-size: 12px; } } @media (min-width: 1025px) { #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title { font-size: 12px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link { font-size: 12px; } } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer.evergreen { background: var(--evgBrand1Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer.evergreen .evergreen-credits .evergreen-container-content { display: flex; flex-direction: column; align-items: center; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-header .evergreen-title .ModuleTitle { line-height: 1; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-credit-item.evergreen-item { display: flex; flex-direction: row; align-items: center; padding-top: 1px; padding-bottom: 2px; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item { background: var(--evgBrand1Color); border-bottom: 0 none; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title { text-transform: none; line-height: 1; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title:not(:hover):not(:focus) { color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title:hover { color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-item-title:focus { color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link { text-transform: none; color: var(--evgBrand3Color); color: var(--evgBrand3Color); color: var(--evgBrand3Color); font-weight: normal; line-height: 1; } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link:not(:hover):not(:focus) { text-decoration: none; text-decoration-color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link:hover { text-decoration-color: var(--evgBrand3Color); } #_ctrl0_FooterPane2_footer_pane_secondary_ctl10_divModuleContainer .evergreen-link:focus { text-decoration-color: var(--evgBrand3Color); } © 2026 Shattuck Labs, Inc. - All rights reserved Powered By Q4 Inc. 5.187.1.9 (opens in new window) q4EvergreenHelpers.stickyNavBar({ layoutSelector: ".evergreen-layout", headerSelector: '.evergreen-section--navigation', navSelector: '.evergreen-pane--navigation', navContainerSelector: '.evergreen-section--navigation', }); //<![CDATA[ var Page_Validators = new Array(document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress"), document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_ctl04"), document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator"), document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha")); //]]> //<![CDATA[ var _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress = document.all ? document.all["_ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress"] : document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress"); _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress.controltovalidate = "_ctrl0_FooterPane_footer_pane_main_ctl10_txtEmailAddress"; _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress.errormessage = "Email Address is required."; _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress.validationGroup = "31eaa96c-e477-4d07-b84a-7978c5850ee9"; _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; _ctrl0_FooterPane_footer_pane_main_ctl10_reqEmailAddress.initialvalue = ""; var _ctrl0_FooterPane_footer_pane_main_ctl10_ctl04 = document.all ? document.all["_ctrl0_FooterPane_footer_pane_main_ctl10_ctl04"] : document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_ctl04"); _ctrl0_FooterPane_footer_pane_main_ctl10_ctl04.controltovalidate = "_ctrl0_FooterPane_footer_pane_main_ctl10_txtEmailAddress"; _ctrl0_FooterPane_footer_pane_main_ctl10_ctl04.errormessage = "Email Address is invalid."; _ctrl0_FooterPane_footer_pane_main_ctl10_ctl04.validationGroup = "31eaa96c-e477-4d07-b84a-7978c5850ee9"; var _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator = document.all ? document.all["_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator"] : document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator"); _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator.errormessage = "Investor Alert Options is required."; _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator.validationGroup = "31eaa96c-e477-4d07-b84a-7978c5850ee9"; _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalMailingListsValidator.evaluationfunction = "CustomValidatorEvaluateIsValid"; var _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha = document.all ? document.all["_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha"] : document.getElementById("_ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha"); _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha.errormessage = "The captcha test has failed. Please try again."; _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha.validationGroup = "31eaa96c-e477-4d07-b84a-7978c5850ee9"; _ctrl0_FooterPane_footer_pane_main_ctl10_cusvalRecaptcha.evaluationfunction = "CustomValidatorEvaluateIsValid"; //]]> //<![CDATA[ var Page_ValidationActive = false; if (typeof(ValidatorOnLoad) == "function") { ValidatorOnLoad(); } function ValidatorOnSubmit() { if (Page_ValidationActive) { return ValidatorCommonOnSubmit(); } else { return true; } } theForm.oldSubmit = theForm.submit; theForm.submit = WebForm_SaveScrollPositionSubmit; theForm.oldOnSubmit = theForm.onsubmit; theForm.onsubmit = WebForm_SaveScrollPositionOnSubmit; //]]>

The release as fetched from its publisher. shattucklabs.com ↗