Phase 1 trial results from a novel long acting NPY2-receptor agonist in partnership between Gubra A/S and Boehringer Ingelheim presented today at the European Congress on Obesity, ECO 2023

BI 1820237 a novel long-acting neuropeptide Y receptor type 2 (NPY2) agonist, has been evaluated in a phase 1 clinical trial. Results to be presented today at the ECO 2023 congress in Dublin, Ireland. The trial showed no unexpected safety concerns, and positive effects on energy intake and gastric emptying. BI 1820237 originates from an ongoing collaboration between Boehringer Ingelheim and Gubra A/S. Today, at the 30th European Congress on Obesity (ECO 2023) in Dublin, Ireland, Boehringer Ingelheim shares phase 1 results for BI 1820237, a long acting NPY2 receptor agonist drug candidate developed in collaboration with Gubra A/S. The phase 1 trial (NCT04903509) was a placebo-controlled study consisting of 3 parts: Part 1: testing single increasing subcutaneous doses of the novel NPY2 receptor agonist, part 2: increasing the number of participants in the high dose group and part 3:  exploring low-to-medium doses of the NPY2 receptor agonist in combination with low-dose liraglutide. Participants in the trial were healthy men with overweight/obesity. The results show no unexpected safety or tolerability concerns with single doses of BI 1820237 with and without liraglutide. Adverse events were primarily gastro-intestinal in nature and the frequency increased with increasing dose. Treatment with BI 1820237 decreased energy intake and delayed gastric emptying in healthy men with overweight/obesity, supporting further investigations of the drug candidate. Niels Vrang, Chief Scientific Officer at Gubra A/S, expressed satisfaction with the results and the continued development of this peptide by Boehringer Ingelheim as a potential anti-obesity medication: “We are excited to see data from the phase 1 trial presented by Boehringer Ingelheim at the annual European Congress on Obesity. Data are in line with observations in several animal models. We look forward to seeing how this NPY2-receptor agonist can be used in combination with approved obesity drugs, e.g. GLP-1 receptor agonists and other obesity drug candidates currently in development, to potentially improve therapy – better effect and/or a better tolerability profile for the benefit for people living with obesity. It will be exciting to follow this project as it moves forward.” Contacts at Gubra Media: Sofia Pitt Boserup, [email protected], +45 4188 9586 Investors: Kristian Borbos, [email protected], +45 3080 8035 About Gubra Gubra, founded in 2008 in Denmark, is specialized in pre-clinical contract research services and peptide-based drug discovery within metabolic and fibrotic diseases. Gubra’s activities are focused on the early stages of drug development and are organised in two business areas – CRO Services and Discovery & Partnerships (D&P). The two business areas are highly synergistic and create a unique entity capable of generating a steady cash flow from the CRO business while at the same time enjoying biotechnology upside in the form of potential development milestone payments and potential royalties from the D&P business. Gubra has approx. 200 employees and had annual revenue of approx. DKK 200 million in 2022. See www.gubra.dk for more information. Attachments Phase 1 trial results from a novel long acting NPY2-receptor agonist in partnership between Gubra A/S and Boehringer Ingelheim presented today at the European Congress on Obesity, ECO 2023 Phase 1 trial results from a novel long acting NPY2-receptor agonist in partnership between Gubra A/S and Boehringer Ingelheim presented today at the European Congress on Obesity, ECO 2023

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