Cancervax Successfully Uses Nobel Prize Chemistry to Achieve Universal Cancer Treatment Targeting Milestone

The UCLA research team created a low cost and customizable lipid nanoparticle using “click chemistry” for precise targeting of cancer cell surface markers Santa Barbara, CA, May 21, 2024 (GLOBE NEWSWIRE) -- Cancervax, Inc., a pre-clinical biotechnology company creating a better way to treat cancer, the developer of breakthrough cancer drugs that will use the body’s immune system to treat cancer, today announced that its UCLA research team has achieved a critical milestone by creating a process to add any antibody to lipid nanoparticles (LNP) using “click chemistry”, for targeting cancer cells. Click chemistry is a revolutionary approach to chemical synthesis that won the Nobel Prize in Chemistry 2022. It is characterized by high efficiency, high reliability, and simplicity in making precise molecular structures, such as LNPs, quickly and cost-effectively. In other words, you “click” together what you need and not anything else. The current approach to manufacturing LNPs uses imprecise melamine chemistry where unwanted materials end up in the final product, leading to toxicity and low efficiency. The LNP is the vehicle that carries the functional cargoes of the Company’s Universal Cancer Treatment to precisely detect, mark and kill cancer cells. UCV uses multiple targeting signals to detect cancer cells with precision, as opposed to the conventional single signal targeting. By using click chemistry, the UCLA team has successfully created a customizable precision LNP architecture where various antibodies can be “clicked” onto the outside. These antibodies only bind to matching proteins (aka antigens) on the cancer cell surface like a lock-and-key mechanism. Once attached to the cell surface, the LNP would then enter the cancer cell and release additional UCV molecules that perform additional matching inside the cell to confirm that the cell is in fact a cancer cell. This multi-signal targeting is the very foundation of UCV’s high precision targeting of cancer cells. Cancervax CEO, Byron Elton, said, “We believe that precision targeting of cancer cells is vital to better patient outcome and higher quality of care. Previous generations of cancer treatments such as chemotherapy, radiation, surgery and even other cancer vaccines are not that precise – as many people already know. Our UCV is a revolutionary concept. It is an outside the box approach that leverages state-of-the-art bioengineering and molecular technologies to develop a better way to treat cancer, by precisely detecting, marking, and killing cancer cells. The UCLA team continues to tell us that they are very excited about this ‘fresh-thinking’ approach and are working tirelessly to advance the development of our Universal Cancer Treatment platform.” About CancerVax CancerVax is a pre-clinical biotech company developing a novel Universal Cancer Treatment platform that will be customizable, as an injection, to treat many types of cancer. Our innovative approach DETECTS, MARKS, and KILLS only cancer cells. By making cancer cells look like well-immunized common diseases, such as measles or chickenpox, we intend to use the body’s natural immune system to easily kill the cancer cells. We look forward to the day when treating cancer will be as simple as getting a shot — a better way to fight cancer. To learn more, please visit www.CancerVax.com Forward-Looking Statements This press release may contain “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Any forward-looking statement made by us in this release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise. Press Contact: Cancervax, Inc. Tel: (805) 356-1810 [email protected]

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