Neuren receives DAYBUE sales milestone payment of US$50m

1 of 2 Neuren (NEU) – ASX Announcement 28 February 2025 Neuren receives first DAYBUE™ sales milestone payment of US$50 million Melbourne, Australia: Neuren Pharmaceuticals (ASX: NEU) announced that it has today received in cash its first sales milestone payment that was due for the first calendar year in which net sales of DAYBUETM (trofinetide) in North America exceed US$250 million. Yesterday Neuren’s partner Acadia Pharmaceuticals reported 2024 net sales of DAYBUE in the United States of US$348.4 million. Neuren’s entitlement to sales milestone payments from commercialization of DAYBUE in North America is summarized in the table below. Sales Milestones1 Net Sales in one calendar year US$m ≥US$250m  50 ≥US$500m 50 ≥US$750m 100 ≥US$1bn 150 1 Each sales milestone payment is payable once only. About Neuren Neuren is developing new drug therapies to treat multiple serious neurological disorders that emerge in early childhood and have no or limited approved treatment options. Recognising the urgent unmet need, all programs have been granted “orphan drug” designation in the United States. Orphan drug designation provides incentives to encourage development of therapies for rare and serious diseases. DAYBUE™ (trofinetide) is approved by the US Food and Drug Administration (FDA) and Health Canada for the treatment of Rett syndrome. Neuren has granted an exclusive worldwide licence to Acadia Pharmaceuticals Inc. for the development and commercialisation of trofinetide. Neuren’s second drug candidate, NNZ-2591, is in development for multiple neurodevelopmental disorders, with positive results achieved in Phase 2 clinical trials in Phelan-McDermid syndrome, Pitt Hopkins syndrome and Angelman syndrome. Contact: [email protected] Jon Pilcher, CEO: +61 438 422 271 2 of 2 ASX Listing Rules information This announcement was authorized to be given to the ASX by the CEO & Managing Director of Neuren Pharmaceuticals Limited, Suite 201, 697 Burke Road, Camberwell, VIC 3124 Forward-looking Statements This announcement contains forward-looking statements that are subject to risks and uncertainties. Such statements involve known and unknown risks and important factors that may cause the actual results, performance or achievements of Neuren to be materially different from the statements in this announcement.

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