VOLUNTARY ANNOUNCEMENT - POTENT ALDOSTERONE SYNTHASE INHIBITOR (SYH2072 TABLETS) OBTAINS CLINICAL TRIAL APPROVAL IN CHINA

Hong Kong Exchanges and Clearing Limited and The Stock Excha nge of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoe ver for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this ann ouncement. CSPC PHARMACEUTICAL GROUP LIMITED (Incorporated in Hong Kong with limited liability) (Stock Code: 1093) ʮ ̡ VOLUNTARY ANNOUNCEMENT POTENT ALDOSTERONE SYNTHASE INHIBITOR (SYH2072 TABLETS) OBTAINS CLINICAL TRIAL APPROVAL IN CHINA The Board of Directors (the ‘‘Board ’’) of CSPC Pharmaceutical Group Limited (the ‘‘Company ’’, together with its subsidiaries, the ‘‘Group ’’) is pleased to announce that a potent aldosterone synthase inhibitor (SYH2072 tablets) (the ‘‘Product ’’), a Class 1 new chemical drug developed by the Group, has obtained approval from the National Medical Products Ad ministration of the People ’s Republic of China to conduct clinical trials in China. The Product is a highly selective and potent aldosterone syn thase inhibitor (ASI) that effectively reduces plasma aldosterone levels without affecting corti sol levels. The indications for this clinical trial approval are uncontrolled hypertension and primary aldost eronism. Pre-clinical studies indicated that the Product selectively inhibited aldosterone synthase ac tivity, significantly reduced plasma aldosterone levels in animal disease models, and dose-dependently lowe red blood pressure in hypertensive models while having no impact on cortisol levels. With favourable p harmacokinetic properties and safety profile, the Product has the potential to become a best-in-c lass therapy. Currently, the Group has submitted multiple patent applications for the Product in C hina and overseas. Given the substantial unmet clinical need for aldosterone s ynthase inhibitors, the Product has high clinical development value and is expected to provide a new t reatment option for patients with uncontrolled hypertension and primary aldosteronism. By order of the Board CSPC Pharmaceutical Group Limited CAI Dong Chen Chairman Hong Kong, 29 December 2025 – 1 – As at the date of this announcement, the Board comprises Mr. C AI Dong Chen, Dr. CAI Lei, Mr. WEI Qingjie, Mr. ZHANG Cuilong, Mr. WANG Zhenguo, Mr. WANG Huaiy u, Dr. LI Chunlei, Dr. YAO Bing, Mr. CAI Xin, Mr. CHEN Weiping and Mr. QU Zhiyong, as Executive Directors; and Mr. WANG Bo, Mr. CHEN Chuan, Prof. WANG Hongguang, Mr. AU Chun Kwok Alan, M r. LAW Cheuk Kin Stephen and Ms. LI Quan as Independent Non-executive Directors. – 2 –

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