Inhaled Beclomethasone to Prevent Chronic Lung Disease

Summary

To test if inhaled glucocorticoids, early in the course of respiratory failure in premature infants, permit normal lung growth and differentiation, thus preventing development of bronchopulmonary dysplasia.

Timeline

Start

1993-06

Primary completion

—

Completion

1999-04

Publications

• Background Cole CH, Colton T, Shah BL, Abbasi S, MacKinnon BL, Demissie S, Frantz ID 3rd. Early inhaled glucocorticoid therapy to prevent bronchopulmonary dysplasia. N Engl J Med. 1999 Apr 1;340(13):1005-10. doi: 10.1056/NEJM199904013401304.
• Background Gupta GK, Cole CH, Abbasi S, Demissie S, Njinimbam C, Nielsen HC, Colton T, Frantz ID 3rd. Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia. Pediatr Pulmonol. 2000 Oct;30(4):275-81. doi: 10.1002/1099-0496(200010)30:43.0.co;2-g.
• Background Arias-Camison JM, Lau J, Cole CH, Frantz ID 3rd. Meta-analysis of dexamethasone therapy started in the first 15 days of life for prevention of chronic lung disease in premature infants. Pediatr Pulmonol. 1999 Sep;28(3):167-74. doi: 10.1002/(sici)1099-0496(199909)28:33.0.co;2-y.
• Background Cole CH, Shah B, Abbasi S, Demissie S, MacKinnon B, Colton T, Frantz ID 3rd. Adrenal function in premature infants during inhaled beclomethasone therapy. J Pediatr. 1999 Jul;135(1):65-70. doi: 10.1016/s0022-3476(99)70329-x.

Drugs

Indications