Asthma Clinical Research Network (ACRN)

Summary

This study will establish a network of interactive asthma clinical research groups to evaluate current therapies, new therapies, and management strategies for adult asthma.

Timeline

Start

1993-09

Primary completion

—

Completion

2008-07

Publications

• Background Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli VM, Drazen JM, Fish JE, Israel E, Lazarus SC, Lemanske RF. Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1739-48. doi: 10.1164/ajrccm.153.6.8665030. No abstract available.
• Background Irvin CG, Martin RJ, Chinchilli VM, Kunselman SJ, Cherniack RM. Quality control of peak flow meters for multicenter clinical trials. The Asthma Clinical Research Network (ACRN). Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):396-402. doi: 10.1164/ajrccm.156.2.9609054.
• Background Martin RJ, Wanger JS, Irvin CG, Bucher Bartelson B, Cherniack RM. Methacholine challenge testing: safety of low starting FEV1. Asthma Clinical Research Network (ACRN). Chest. 1997 Jul;112(1):53-6. doi: 10.1378/chest.112.1.53.
• Background Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1165-71. doi: 10.1164/ajrccm.156.4.9703012.
• Background Martin RJ, Pak J, Kunselman SJ, Cherniack RM. Assessment of the AirWatch lung function monitoring system. Asthma Clinical Research Network (ACRN). J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):535-6. doi: 10.1016/s0091-6749(99)70484-7. No abstract available.
• Background Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med. 1996 Sep 19;335(12):841-7. doi: 10.1056/NEJM199609193351202.
• Background Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest. 2001 Apr;119(4):1027-33. doi: 10.1378/chest.119.4.1027.
• Background Lemanske RF Jr, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ; Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA. 2001 May 23-30;285(20):2594-603. doi: 10.1001/jama.285.20.2594.
• Background Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF Jr, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ; Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA. 2001 May 23-30;285(20):2583-93. doi: 10.1001/jama.285.20.2583.
• Background Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul;162(1):75-80. doi: 10.1164/ajrccm.162.1.9907092.
• Background Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF Jr, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):183-6. doi: 10.1159/000053705.
• Background Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ; NHLBI Asthma Clinical Research Network. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001 May;163(6):1470-5. doi: 10.1164/ajrccm.163.6.9901105.
• Background King TS, Chinchilli VM. Robust estimators of the concordance correlation coefficient. J Biopharm Stat. 2001;11(3):83-105. doi: 10.1081/BIP-100107651.
• Background Sorkness CA, Ford JG, Lemanske RF Jr; Asthma Clinical Trials Network. Recruitment strategies in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):222S-35S. doi: 10.1016/s0197-2456(01)00172-6.
• Background Martin RJ, Kephart DK, Dyer AM, Fahy J, Kraft M; Asthma Clinical Trials Network. Quality control within the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):207S-21S. doi: 10.1016/s0197-2456(01)00164-7.
• Background Forand PE, Kunselman SJ, Drazen JM, Israel E, Pillari A, Armstrong TJ, Britton TB; Asthma Clinical Trials Network. Genetic analysis in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):196S-206S. doi: 10.1016/s0197-2456(01)00163-5.
• Background Kunselman SJ, Armstrong TJ, Britton TB, Forand PE; Asthma Clinical Trials Network. Implementing randomization procedures in the asthma clinical research network. Control Clin Trials. 2001 Dec;22(6 Suppl):181S-95S. doi: 10.1016/s0197-2456(01)00162-3.
• Background Pogash RM, Boehmer SJ, Forand PE, Dyer AM, Kunselman SJ; Asthma Clinical Trials Network. Data management procedures in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):168S-80S. doi: 10.1016/s0197-2456(01)00170-2.
• Background Hess HM, Curley RM, Chinchilli VM, Cherniack RM, Evans RL; Asthma Clinical Trials Network. Modem remote support of pulmonary-function testing and quality control systems. Control Clin Trials. 2001 Dec;22(6 Suppl):156S-67S. doi: 10.1016/s0197-2456(01)00169-6.
• Background Curley RM, Evans RL, Kaylor J, Pogash RM, Chinchilli VM; Asthma Clinical Trials Network. Development and deployment of an internet-based data management system for use by the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):135S-55S. doi: 10.1016/s0197-2456(01)00174-x.
• Background Chinchilli VM, Drazen JM, Fish JE, Lemanske RF Jr, Lazarus SC, Martin RJ; Asthma Clinical Trials Network. The clinical trials in the initial five-year award period of the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):126S-34S. doi: 10.1016/s0197-2456(01)00160-x.
• Background Kephart DK, Chinchilli VM, Hurd SS, Cherniack RM; Asthma Clinical Trials Network. The organization of the Asthma Clinical Research Network: a multicenter, multiprotocol clinical trials team. Control Clin Trials. 2001 Dec;22(6 Suppl):119S-25S. doi: 10.1016/s0197-2456(01)00161-1.
• Background Chinchilli VM. The Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):117S-8S. doi: 10.1016/s0197-2456(01)00173-8. No abstract available.
• Background Janson SL, Alioto ME, Boushey HA; Asthma Clinical Trials Network. Attrition and retention of ethnically diverse subjects in a multicenter randomized controlled research trial. Control Clin Trials. 2001 Dec;22(6 Suppl):236S-43S. doi: 10.1016/s0197-2456(01)00171-4.
• Background Mauger EA, Mauger DT, Fish JE, Chinchilli VM, Israel E; Asthma Clinical Trials Network. Summarizing methacholine challenges in clinical research. Control Clin Trials. 2001 Dec;22(6 Suppl):244S-51S. doi: 10.1016/s0197-2456(01)00159-3.
• Background Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15;165(10):1377-83. doi: 10.1164/rccm.2105013.
• Background Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF Jr, Mauger E, Peters SP, Sorkness CA; Asthma Clinical Research Network of the National Heart Lung, and Blood Institute. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar;109(3):410-8. doi: 10.1067/mai.2002.122635.
• Background McEntegart D. Implementing randomization procedures in the Asthma Clinical Research Network. Control Clin Trials. 2002 Aug;23(4):424-6; author reply 426-8. doi: 10.1016/s0197-2456(02)00210-6. No abstract available.
• Background Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF Jr, Szefler SJ; Asthma Clinical Research Network. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest. 2003 Jul;124(1):42-50. doi: 10.1378/chest.124.1.42.
• Background Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK; Genetics of Asthma in Latino Americans (GALA) Study. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 1;169(3):386-92. doi: 10.1164/rccm.200309-1293OC. Epub 2003 Nov 14.
• Background Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, Gonzalez Burchard E. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 1;168(11):1312-6. doi: 10.1164/rccm.200306-877OC. Epub 2003 Sep 4.
• Background Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 1;13(13):1353-9. doi: 10.1093/hmg/ddh149. Epub 2004 May 5.
• Background Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23-29;364(9444):1505-12. doi: 10.1016/S0140-6736(04)17273-5.
• Background Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E; Asthma Clinical Research Network, National Heart, Lung, and Blood Institute/NIH. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005 Apr;115(4):720-7. doi: 10.1016/j.jaci.2004.12.1129.
• Background Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF Jr, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005 Apr 14;352(15):1519-28. doi: 10.1056/NEJMoa042552.
• Background Fabbri LM. Does mild persistent asthma require regular treatment? N Engl J Med. 2005 Apr 14;352(15):1589-91. doi: 10.1056/NEJMe058020. No abstract available.

Drugs

Indications