drugset / Trial / NCT00002622
Talc in Treating Patients With Malignant Pleural Effusion
Phase 3
Completed
501 enrolled
Alliance for Clinical Trials in Oncology
Eastern Cooperative Oncology Group · collabNational Cancer Institute (NCI) · collabNorth Central Cancer Treatment Group · collabRadiation Therapy Oncology Group · collab
RandomizedParallel-groupOpen-labelSupportive care
Summary
RATIONALE: Talc may relieve malignant pleural effusion. It is not yet known whether wet talc is more effective than dry talc in treating patients with malignant pleural effusion. PURPOSE: Randomized phase III trial to compare the effectiveness of wet talc with dry talc in treating patients with malignant pleural effusion.
Timeline
- Start
- 1994-12
- Primary completion
- 2005-03
- Completion
- 2006-01
Publications
- Results Dresler CM, Olak J, Herndon JE 2nd, Richards WG, Scalzetti E, Fleishman SB, Kernstine KH, Demmy T, Jablons DM, Kohman L, Daniel TM, Haasler GB, Sugarbaker DJ; Cooperative Groups Cancer and Leukemia Group B; Eastern Cooperative Oncology Group; North Central Cooperative Oncology Group; Radiation Therapy Oncology Group. Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion. Chest. 2005 Mar;127(3):909-15. doi: 10.1378/chest.127.3.909.
- Results Fleishman SB, Dresler C, Herndon JE, et al.: Quality of life (QOL) advantage of sclerosis for malignant pleural effusion (MPE) via talc thoracoscopy over chest tube infusion of talc slurry: a cancer and leukemia group B study. [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-1418, 2002.
- Results Dresler CM, Herndon JE, Daniels T, et al.: Cancer and Leukemia Group B (CALGB) 9334: a phase III, intergroup study of sclerosis of malignant pleural effusion by talc. [Abstract] Proceedings of the American Society of Clinical Oncology 19: A2455, 2000.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | TALC ANHYDROUS | Small molecule | 4 g | Other |
| Comparator | TALC ANHYDROUS | Small molecule | 5 g | Other |