Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus

Phase 2 Terminated 30 enrolled Gynecologic Oncology Group National Cancer Institute (NCI) · collab

Treatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy with mitomycin, doxorubicin, and cisplatin in treating patients with recurrent or advanced cancer of the uterus.

Timeline

Start: 1997-08
Primary completion: 2000-01
Completion: —

Publications

Results Edmonson JH, Blessing JA, Cosin JA, Miller DS, Cohn DE, Rotmensch J. Phase II study of mitomycin, doxorubicin, and cisplatin in the treatment of advanced uterine leiomyosarcoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2002 Jun;85(3):507-10. doi: 10.1006/gyno.2002.6661.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cisplatin	Other / unclassified	60 mg/m2	Intravenous
Subject	Doxorubicin	Other / unclassified	40 mg/m2	Intravenous
Subject	Mitomycin C	Other / unclassified	8 mg/m2	Intravenous

Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus

Summary

Timeline

Publications

Drugs

Indications