drugset / Trial / NCT00003005
Chemotherapy With Cordycepin Plus Pentostatin in Treating Patients With Refractory Acute Lymphocytic or Chronic Myelogenous Leukemia
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of chemotherapy consisting of cordycepin plus pentostatin in treating patients with refractory acute lymphocytic or chronic myelogenous leukemia.
Timeline
- Start
- 1997-12
- Primary completion
- 2001-03
- Completion
- 2001-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cordycepin | Small molecule | 6 mg/m2 | Intravenous |
| Subject | Cordycepin | Small molecule | 12 mg/m2 | Intravenous |
| Subject | Cordycepin | Small molecule | 24 mg/m2 | Intravenous |
| Subject | Cordycepin | Small molecule | 48 mg/m2 | Intravenous |
| Subject | Pentostatin | Small molecule | 2 mg/m2 | Intravenous |
| Subject | Pentostatin | Small molecule | 3 unknown | Intravenous |