Vinblastine and Methotrexate in Treating Children With Desmoid Tumors

Phase 2 Completed 28 enrolled Children's Oncology Group Children's Cancer Group · collab National Cancer Institute (NCI) · collab

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy with vinblastine and methotrexate in treating children who have desmoid tumors that are recurrent or untreatable with surgery or radiation therapy.

Timeline

Start: 1997-08
Primary completion: 2003-07
Completion: 2006-09

Publications

Results Skapek SX, Ferguson WS, Granowetter L, Devidas M, Perez-Atayde AR, Dehner LP, Hoffer FA, Speights R, Gebhardt MC, Dahl GV, Grier HE; Pediatric Oncology Group. Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial. J Clin Oncol. 2007 Feb 10;25(5):501-6. doi: 10.1200/JCO.2006.08.2966.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methotrexate	Small molecule	30 mg/m2	Intravenous
Subject	Vinblastine	Small molecule	5 mg/m2	Intravenous

Vinblastine and Methotrexate in Treating Children With Desmoid Tumors

Summary

Timeline

Publications

Drugs

Indications