drugset / Trial / NCT00003698
Chemotherapy in Treating Patients With Solid Tumors
Treatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of combretastatin A4 phosphate in treating patients who have advanced malignant solid tumors.
Timeline
- Start
- 1998-07
- Primary completion
- —
- Completion
- 2003-12
Publications
- Background Galbraith SM, Taylor NJ, Maxwell RJ, et al.: Combretastatin A4 phosphate (CA4P) targets vasculature in animal and human tumors. [Abstract] Br J Cancer 83 (suppl 1): A-1.7, 12, 2000.
- Results Rustin GJ, Galbraith SM, Anderson H, Stratford M, Folkes LK, Sena L, Gumbrell L, Price PM. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol. 2003 Aug 1;21(15):2815-22. doi: 10.1200/JCO.2003.05.185. Epub 2003 Jun 13.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | fosbretabulin | Small molecule | 5 mg/m2 | Intravenous |
| Subject | fosbretabulin | Small molecule | 52 mg/m2 | Intravenous |
| Subject | fosbretabulin | Small molecule | 68 mg/m2 | Intravenous |
| Subject | fosbretabulin | Small molecule | 88 mg/m2 | Intravenous |
| Subject | fosbretabulin | Small molecule | 114 mg/m2 | Intravenous |