drugset
drugset / Trial / NCT00004074

Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu

NCT00004074 ↗

Phase 1 Completed 15 enrolled National Cancer Institute (NCI)
NaSingle-groupOpen-labelTreatment

Summary

Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill cancer cells. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Phase I trial to study the effectiveness of interleukin-12 and trastuzumab in treating patients who have cancer that has high levels of HER2/neu and has not responded to previous therapy

Timeline

Start
1999-08
Primary completion
2009-02
Completion
—

Drugs

EvaluationDrugModalityDoseRoute
Subject Trastuzumab Monoclonal antibody — Intravenous
Subject interleukin-12 Protein / enzyme biologic — Intravenous
Background Carboplatin Small molecule — Intravenous
Background Paclitaxel Small molecule — Intravenous

Indications

PPoma adenoid cystic carcinoma adrenal cortex carcinoma anal squamous cell carcinoma appendix carcinoma cancer of unknown primary site cervical carcinoma endometrial carcinoma esophageal cancer exocrine pancreatic carcinoma extrahepatic bile duct carcinoma fallopian tube cancer female breast carcinoma gallbladder carcinoma gastric carcinoma gastrin-producing neuroendocrine tumor glucagonoma infiltrating urothelial carcinoma inflammatory breast carcinoma laryngeal squamous cell carcinoma lip and oral cavity squamous cell carcinoma lung carcinoid tumor lytic metastatic bone lesion male breast carcinoma malignant testicular germ cell tumor medullary thyroid gland carcinoma nasopharyngeal squamous cell carcinoma non-small cell lung carcinoma oral cavity mucoepidermoid carcinoma oropharynx squamous cell carcinoma ovarian carcinoma pancreatic cholera pancreatic insulinoma parathyroid gland carcinoma pericardial effusion pleural cancer primary peritoneal carcinoma prostate carcinoma renal pelvis/ureter urothelial carcinoma salivary gland cancer skin cancer small intestine adenocarcinoma somatostatinoma thyroid gland papillary carcinoma thyroid gland undifferentiated (anaplastic) carcinoma urethra cancer urinary bladder carcinoma vaginal carcinoma vulvar carcinoma