Combination Chemotherapy Followed by Surgery in Treating Patients With Stomach Cancer

Phase 2 Completed NYU Langone Health National Cancer Institute (NCI) · collab

Treatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and combining chemotherapy with surgery may kill more tumor cells. PURPOSE: This phase II trial is studying how well irinotecan and cisplatin followed by surgery, floxuridine, and cisplatin work in treating patients with stomach cancer.

Timeline

Start: 1998-07
Primary completion: 2007-03
Completion: 2009-06

Publications

Results Newman E, Potmesil M, Ryan T, Marcus S, Hiotis S, Yee H, Norwood B, Wendell M, Muggia F, Hochster H. Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase II study. Semin Oncol. 2005 Dec;32(6 Suppl 9):S97-100. doi: 10.1053/j.seminoncol.2005.06.002.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cisplatin	Other / unclassified	25 mg/m2	Intravenous
Subject	Cisplatin	Other / unclassified	60 mg/m2	Intravenous
Subject	Floxuridine	Unknown	3 g	Other
Subject	Irinotecan	Small molecule	75 mg/m2	Intravenous

Combination Chemotherapy Followed by Surgery in Treating Patients With Stomach Cancer

Summary

Timeline

Publications

Drugs

Indications