Green Tea Extract in Treating Patients With Actinic Keratosis

Phase 2 Terminated 88 enrolled Frank Meyskens National Cancer Institute (NCI) · collab

RandomizedParallel-groupDouble-blindPrevention

Summary

RATIONALE: Green tea extract contains ingredients that may inhibit the growth of actinic keratosis. PURPOSE: Randomized phase II trial to determine the effectiveness of green tea extract in treating patients who have actinic keratosis.

Timeline

Start: 1999-08
Primary completion: 2002-08
Completion: 2002-08

Outcome

Outcome not reported

Stopped: “terminated due to the low conditional power for a positive study”

Publications

Results Carpenter PM, Linden KG, McLaren CE, Li KT, Arain S, Barr RJ, Hite P, Sun JD, Meyskens FL Jr. Nuclear morphometry and molecular biomarkers of actinic keratosis, sun-damaged, and nonexposed skin. Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):1996-2002.
Results Linden KG, Carpenter PM, McLaren CE, Barr RJ, Hite P, Sun JD, Li KT, Viner JL, Meyskens FL. Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea. Recent Results Cancer Res. 2003;163:165-71; discussion 264-6. doi: 10.1007/978-3-642-55647-0_15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Epigallocatechin gallate	Small molecule	—	Topical