Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Phase 1 Completed Memorial Sloan Kettering Cancer Center National Cancer Institute (NCI) · collab

Treatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy in treating patients who have locally advanced or metastatic solid tumors.

Timeline

Start: 1999-10
Primary completion: 2002-07
Completion: 2009-12

Publications

Results Ku GY, O'Reilly EM, Saltz LB, Schrag D, Maki RG, Kelsen DP, Ilson DH. Phase I study of weekly cisplatin, bolus fluorouracil and escalating doses of irinotecan in advanced solid tumors. Cancer Invest. 2009 May;27(4):402-6. doi: 10.1080/07357900802406327.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cisplatin	Other / unclassified	25 mg/m2	Intravenous
Subject	Irinotecan	Small molecule	40 mg/m2	Intravenous
Subject	Irinotecan	Small molecule	50 mg/m2	Intravenous
Subject	Irinotecan	Small molecule	65 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	425 mg/m2	Intravenous

Indications

No indication recorded.