drugset / Trial / NCT00007787

Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants

NCT00007787

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to see if kidney function can be improved during transplants by giving the drug Thymoglobulin with delayed cyclosporine treatment instead of initial cyclosporine treatment. There have been improvements for patients receiving kidney transplants, yet acute rejection is still a problem. This can lead to kidney failure over time. Patients whose graft fails to function properly in the first week after transplant do not do as well after 5 years as compared to patients without early problems. This study will see if Thymoglobulin, a drug that suppresses the immune system, will improve early graft function.

Timeline

Start
2000-04
Primary completion
Completion
2004-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Cyclosporine Peptide
Subject Thymoglobulin Protein / enzyme biologic 1.5 mg/kg
Background Tacrolimus Small molecule