Shark Cartilage in Treating Patients With Advanced Colorectal or Breast Cancer

Phase 3 Completed 88 enrolled Alliance for Clinical Trials in Oncology National Cancer Institute (NCI) · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

RATIONALE: Shark cartilage extract may help shrink or slow the growth of colorectal cancer or breast cancer cells. PURPOSE: Randomized phase III trial to determine the effectiveness of shark cartilage in treating patients who have advanced colorectal cancer or advanced breast cancer.

Timeline

Start: 2001-08
Primary completion: 2006-09
Completion: 2006-09

Outcome

Missed primary endpoint

paper There was no difference in overall survival between patients receiving standard care plus a shark cartilage product versus standard care plus placebo. PMID 15912493 ↗

Publications

Results Loprinzi CL, Levitt R, Barton DL, Sloan JA, Atherton PJ, Smith DJ, Dakhil SR, Moore DF Jr, Krook JE, Rowland KM Jr, Mazurczak MA, Berg AR, Kim GP; North Central Cancer Treatment Group. Evaluation of shark cartilage in patients with advanced cancer: a North Central Cancer Treatment Group trial. Cancer. 2005 Jul 1;104(1):176-82. doi: 10.1002/cncr.21107.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BenFin	Unknown	—	Oral